Evidence map›Paper›PMID 30158963›Full record

ArticleGastroenterology research and practice2018

Pattern of the First Recurrence Has No Impact on Long-Term Survival after Curative Intent Surgery for Perihilar Cholangiocarcinomas.

Madalina Maria Blaga, Vladislav Brasoveanu, Cezar Stroescu, Mihnea Ionescu, Irinel Popescu, Traian Dumitrascu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Madalina Maria Blaga"Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu No. 37, 030167 Bucharest, Romania.
Vladislav BrasoveanuCenter of General Surgery and Liver Transplant, Fundeni Clinical Institute, Fundeni No. 258, 022328 Bucharest, Romania.
Cezar Stroescu"Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu No. 37, 030167 Bucharest, Romania.
Mihnea Ionescu"Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu No. 37, 030167 Bucharest, Romania.
Irinel PopescuCenter of General Surgery and Liver Transplant, Fundeni Clinical Institute, Fundeni No. 258, 022328 Bucharest, Romania.
Traian Dumitrascu"Carol Davila" University of Medicine and Pharmacy, Dionisie Lupu No. 37, 030167 Bucharest, Romania.ORCID 0000-0002-5343-7180
Carol Davila University of Medicine and Pharmacy · ROTitu Maiorescu University · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo explore the pattern of the first recurrence and impact on long-term survival after curative intent surgery for perihilar cholangiocarcinomas (PHC). MATERIALS AND

methodsPatients with curative intent surgery for PHC between 1996 and 2017 were analyzed. Survival times were estimated using the Kaplan-Meier method. Comparisons were made with the log-rank test.

resultsA number of 139 patients were included. The median overall survival was 26 months. A recurrence was observed in 86 patients (61.9%), during a median follow-up time of 89 months. The median disease-free survival was 21 months with 1-, 3-, 5-, and 10-year estimated recurrence rates of 38%, 60%, 69%, and 77%, respectively. A number of 57 patients (41%) developed distant only recurrence, while 26 patients (18.7%) presented local and distant recurrences. An isolated local recurrence was observed in 3 patients (2.2%). The median overall survival was 15 months for patients with local recurrence, 15 months for patients with liver metastases, and 17 months for patients with peritoneal carcinomatosis (

conclusionCurative intent surgery for PHC is associated with high recurrence rates. Most patients will develop distant metastases, while an isolated local recurrence is uncommon. The pattern of recurrence does not appear to have a significant impact on survivals.

Identifiers

PMID30158963
PMCPMC6109483
OpenAlexW2886396444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.