ArticleJournal of oral and maxillofacial pathology : JOMFP
Immunohistochemical study of alpha-smooth muscle actin in odontogenic cysts and tumors.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Review
- Direct and indirect effects of PGF2α administration in male Wistar rats based on increased expression of α-SMA and androgen receptor.Open veterinary journal · 2024Article
- Spatial transcriptomic interrogation of the tumour-stroma boundary in a 3D engineered model of ameloblastoma.Materials today. Bio · 2024Article
- Three-Dimensional Histological Characterization of the Placental Vasculature Using Light Sheet Microscopy.Biomolecules · 2023Article
- Modelling stromal compartments to recapitulate the ameloblastoma tumour microenvironment.Matrix biology plus · 2022Article
- Case report: Presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dog.Frontiers in veterinary science · 2022Article
- Immunohistochemical evaluation of myofibroblasts in odontogenic keratocyst, dentigerous cyst and different clinical variants of ameloblastoma: A comparative study.Dental research journal · 2021Article
- Myofibroblasts and increased angiogenesis contribute to periapical cystic injury containment and repair.Medicina oral, patologia oral y cirugia bucal · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextMyofibroblasts (MFs) are fibroblasts with smooth muscle-like features characterized by the presence of a contractile apparatus. Alpha-smooth muscle actin (α-SMA) is the actin isoform that predominates within vascular smooth muscle cells and plays an important role in fibrogenesis. MFs are metabolically and morphologically distinctive fibroblasts expressing α-SMA, and their activation plays a key role in development of the fibrotic response. AIMS AND
objectivesThe aim of this study is to demonstrate the frequency, distribution and expression of α-SMA-positive MFs in odontogenic keratocyst (OKC), dentigerous cyst (DC) and ameloblastoma and correlate it to their aggressive biological behavior. SETTINGS AND
designA retrospective study of 45 diagnosed cases, which includes 15 cases of OKC, 15 cases of DC and 15 cases of ameloblastoma, was undertaken to demonstrate expression of α-SMA retrieved from archives of our department. MATERIALS AND
methodsα-SMA mouse anti-human antibody and horseradish peroxidase detection system were used in this study. STATISTICAL ANALYSIS: Descriptive statistical analysis and ANOVA test were used for statistical analysis.
resultsThe difference in mean α-SMA count was found to be statistically significant between ameloblastoma and DC group (
conclusionThe present study has shown that the mean number of MFs was higher in OKC and ameloblastoma, while the mean number of MFs in DC was quite low and significantly different from that of ameloblastoma and OKC.
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