Evidence map›Paper›PMID 30158740›Full record

ReviewJournal of toxicologic pathology2018

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System.

Annamaria Brändli-Baiocco, Emmanuelle Balme, Marc Bruder, Sundeep Chandra, Juergen Hellmann, Mark J Hoenerhoff, Takahito Kambara, Christian Landes, Barbara Lenz, Mark Mense and 8 more

Open access · diamondAbstract readReview
In one paragraph

Review in Journal of toxicologic pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
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  4. Optimization of anToxicology reports · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 6 countries.

Annamaria Brändli-BaioccoRoche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.
Emmanuelle BalmeBoehringer Ingelheim Pharma, Biberach an der Riss, Germany.
Marc BruderCompugen, Inc., Nonclinical Safety, South San Francisco, California, USA.
Sundeep ChandraBioMarin Pharmaceuticals Inc., San Rafael, California, USA.
Juergen HellmannMerck KGaA, D64293 Darmstadt, Germany.
Mark J HoenerhoffIn Vivo Animal Core, Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, Michigan USA.
Takahito KambaraAbbVie, Preclinical Safety, North Chicago, Illinois, USA.
Christian LandesRoche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.
Barbara LenzRoche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.
Mark MenseCovance, Chantilly, Virginia, USA.
Susanne RittinghausenFraunhofer ITEM, Department of Pathology, Hannover, Germany.
Hiroshi SatohIwate University, Faculty of Agriculture, Iwate, Japan.
Frédéric SchorschBayer CropScience, Sophia-Antipolis, Cedex, France.
Frank SeeligerAstraZeneca Pathology, Drug Safety and Metabolism, IMED Biotech Unit, Gothenburg, Sweden.
Takuji TanakaTohkai Cytopathology Institute, Cancer Research and Prevention, Gifu, Japan.
Minoru TsuchitaniLSI Medience Corporation, Nonclinical Research Center, Ibaraki, Japan.
Zbigniew WojcinskiToxicology & Pathology Consulting, LLC, Ann Arbor, Michigan, USA.
Thomas J RosolOhio University, Department of Biomedical Sciences, Athens, Ohio, USA.
Roche (Switzerland) · CHAbbVie (United States) · USAstraZeneca (Sweden) · SEBayer (France) · FRBioMarin (United States) · USBoehringer Ingelheim (Germany) · DECovance (United States) · USFraunhofer Institute for Toxicology and Experimental Medicine · DEIwate University · JPMerck (Germany) · DEOhio University · USOkazaki Institute for Integrative Bioscience · JPUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the endocrine organs (pituitary gland, pineal gland, thyroid gland, parathyroid glands, adrenal glands and pancreatic islets) of laboratory rats and mice, with color photomicrographs illustrating examples of the lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for endocrine lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

Indexed as

adrenalC cellschief cellscortical cellsdiagnostic pathologyfollicular cellshypophysisisletsislets of Langerhansmedullary cellsnomenclaturepancreasparathyroidpinealpinealocytespituicytespituitarythyroid

Identifiers

PMID30158740
PMCPMC6108091
OpenAlexW2884984539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.