ArticleNature2018
Required growth facilitators propel axon regeneration across complete spinal cord injury.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 282 papers.
0numbers the graph read from it
0cells of the map it votes in
282citing papers in PubMed
20.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
282 citing papers in PubMed, 529 citations in OpenAlex.
- Engineering functional vasculatures to reconstruct sympathetic-parasympathetic circuits for bladder function after spinal cord injury.Bioactive materials · 2027Article
- Review
- Optogenetic-enabled biomanufacturing of long-projecting motor tracts for neural reconstruction.Biofabrication · 2026Article
- Extensive restoration of forelimb function in primates with spinal cord injury by neural stem cell transplantation.Nature biotechnology · 2026Article
- Treadmill Training Improves Functional Recovery After Injection of Adipose-Derived Stromal Vascular Fraction in Rats With a Spinal Cord Injury.Journal of neuroscience research · 2026Article
- Intramedullary injection of polymerized laminin in acute traumatic spinal cord injury: a first-in-human pilot study.Spinal cord · 2026Article
- PTPσ mediates the integration of grafted neuronal tissueoids with host neural pathways after complete spinal cord injury.Science China. Life sciences · 2026Article
- Microtubules in Spinal Cord Injury: From Cytoskeletal Dysregulation to Therapeutic Regeneration.Journal of neurochemistry · 2026Review
- Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar-Limited Repair in Adult Spinal Cord Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Restoring neuroplasticity after CNS trauma: cell therapy approaches in spinal cord and traumatic brain injury.Journal of translational medicine · 2026Review
- Commentary on: "Targeting fibrotic scarring by mechanoregulation of Il11ra1 + /Itga11 + fibroblast patterning promotes axon growth after spinal cord injury".Neural regeneration research · 2026Article
- Exercise training promotes nerve cell repair and regeneration after spinal cord injury.Neural regeneration research · 2026Article
- Widespread AAV-mediated CSPG digestion impairs functional recovery after cervical spinal cord injury.bioRxiv : the preprint server for biology · 2026Article
- Hopx(+) optic nerve head-astrocytes counter neuronal stress and glaucoma damage.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regeneration and neural circuit reconstruction via FGF13/CaMaterials today. Bio · 2026Article
- Simulated closed-loop magnetic stimulation promotes function recovery and axonal regeneration in spinal cord injury.Communications biology · 2026Article
- Regeneration after Spinal Cord Injury: A Review on the Crucial Aspects of V2a Interneurons.Journal of neurotrauma · 2026Article
- Persistent histone H3K27 acetylation contributes to excessive scar formation after spinal cord injury through the regulation of microglial cholesterol accumulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- TGF-β-induced fibrotic scar formation limits recovery of spinal cord injury.Bone research · 2026Article
- FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair.Journal of neuroinflammation · 2026Article
222 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 2 countries.
Mark A AndersonDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Timothy M O'SheaDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Joshua E BurdaDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Yan AoDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Sabry L BarlateyCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Alexander M BernsteinDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jae H KimDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Nicholas D JamesCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
Alexandra RogersDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Brian KatoDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Alexander L WollenbergDepartments of Bioengineering, Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Riki KawaguchiDepartments of Psychiatry and Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Giovanni CoppolaDepartments of Psychiatry and Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Chen WangF.M. Kirby Neurobiology Center, Department of Neurology, Children's Hospital, Harvard Medical School, Boston, MA, USA.
Timothy J DemingDepartments of Bioengineering, Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Zhigang HeF.M. Kirby Neurobiology Center, Department of Neurology, Children's Hospital, Harvard Medical School, Boston, MA, USA.
Gregoire CourtineCenter for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland. gregoire.courtine@epfl.ch.
Michael V SofroniewDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. sofroniew@mednet.ucla.edu.
University of California, Los Angeles · USÉcole Polytechnique Fédérale de Lausanne · CHHarvard University · US
Funding
Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI · 2009 to 2018
$7.4MInjectable biomaterial depots to manipulate scar and foster axon growth after SCIR01NS084030 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOFRONIEW, MICHAEL V · 2014 to 2023
$3.0MPromoting axon regeneration and functional recovery after SCIR01NS096294 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI HE, ZHIGANG · 2016 to 2020
$1.9MAstrocyte Regulation of Neural Plasticity After CNS InjuryR00NS105915 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI BURDA, JOSHUA EVAN · 2019 to 2021
$739kAstrocyte regulation of neural plasticity after CNS injuryK99NS105915 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BURDA, JOSHUA EVAN · 2018 to 2019
$186kAstrocyte regulation of intraspinal plasticity and spontaneous recovery after SCIF32NS096858 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BURDA, JOSHUA EVAN · 2016 to 2017
$119kEuropean Research Council 682999NINDS NIH HHS F32 NS096858NINDS NIH HHS K99 NS105915NINDS NIH HHS P30 NS062691NINDS NIH HHS R00 NS105915NINDS NIH HHS R01 NS084030NINDS NIH HHS R01 NS096294Swiss National Science Foundation 164220
Abstract
Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury
Indexed as
AnimalsAstrocytesAxonsCicatrixElectrophysiologyEpidermal Growth FactorFemaleFibroblast Growth FactorsGlial Cell Line-Derived Neurotrophic FactorHydrogelsLamininMaleMiceMice, Inbred C57BLNerve RegenerationNeurogliaEpidermal Growth FactorFibroblast Growth FactorsGlial Cell Line-Derived Neurotrophic FactorHydrogelsLamininProteoglycans
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.