ArticleNature genetics2018
Genetic risks and clinical rewards.
Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04331535 (Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care
Who cites it
17 citing papers in PubMed.
- Recurrent Copy Number Variants and Psychiatric Outcomes in the Context of Polygenic Scores.JAMA psychiatry · 2026Article
- Article
- The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory.American journal of human genetics · 2026Article
- Greater value add from electronic health records than polygenic risk scores for predicting myocardial infarction in machine learning.Communications medicine · 2025Article
- Deep learning-based polygenic scores enhance generalizability of psychiatric disorders prediction.medRxiv : the preprint server for health sciences · 2025Article
- Identifying and characterizing disease subpopulations that most benefit from polygenic risk scores.Scientific reports · 2024Article
- The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank.GeroScience · 2024Article
- Holy Grail: the journey towards disease modification in asthma.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Asthma and the Missing Heritability Problem: Necessity for Multiomics Approaches in Determining Accurate Risk Profiles.Frontiers in immunology · 2022Review
- The importance of increasing population diversity in genetic studies of type 2 diabetes and related glycaemic traits.Diabetologia · 2021Review
- Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk.American journal of human genetics · 2020Article
- Strategies for Testing Intervention Matching Schemes in Cancer.Clinical pharmacology and therapeutics · 2020Review
- Genetic Risk Scores.Current protocols in human genetics · 2019Review
- Towards a Better Classification and Novel Therapies Based on the Genetics of Systemic Sclerosis.Current rheumatology reports · 2019Review
- Does big data require a methodological change in medical research?BMC medical research methodology · 2019Article
- Artificial Intelligence and Personalized Medicine.Cancer treatment and research · 2019Article
- Genomic Predictors of Asthma Phenotypes and Treatment Response.Frontiers in pediatrics · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.