Evidence map›Paper›PMID 30158584›Full record

ArticleNature communications2018

An imputation platform to enhance integration of rice genetic resources.

Diane R Wang, Francisco J Agosto-Pérez, Dmytro Chebotarov, Yuxin Shi, Jonathan Marchini, Melissa Fitzgerald, Kenneth L McNally, Nickolai Alexandrov, Susan R McCouch

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Diane R WangSection of Plant Breeding and Genetics, School of Integrated Plant Sciences, Cornell University, Ithaca, NY, 14853-1901, USA.ORCID http://orcid.org/0000-0002-2290-3257
Francisco J Agosto-PérezSection of Plant Breeding and Genetics, School of Integrated Plant Sciences, Cornell University, Ithaca, NY, 14853-1901, USA.
Dmytro ChebotarovInternational Rice Research Institute, DAPO Box 7777,, 1301, Metro Manila, Philippines.
Yuxin ShiSection of Plant Breeding and Genetics, School of Integrated Plant Sciences, Cornell University, Ithaca, NY, 14853-1901, USA.
Jonathan MarchiniDepartment of Statistics, University of Oxford, Oxford, OX1 3LB, UK.ORCID http://orcid.org/0000-0003-0610-8322
Melissa FitzgeraldSchool of Agriculture and Food Science, University of Queensland, 4072, QLD, Brisbane, Australia.ORCID http://orcid.org/0000-0002-0761-764X
Kenneth L McNallyInternational Rice Research Institute, DAPO Box 7777,, 1301, Metro Manila, Philippines.ORCID http://orcid.org/0000-0002-9613-5537
Nickolai AlexandrovInternational Rice Research Institute, DAPO Box 7777,, 1301, Metro Manila, Philippines.ORCID http://orcid.org/0000-0002-5419-2197
Susan R McCouchSection of Plant Breeding and Genetics, School of Integrated Plant Sciences, Cornell University, Ithaca, NY, 14853-1901, USA. srm4@cornell.edu.ORCID http://orcid.org/0000-0001-9246-3106
Cornell University · USInternational Rice Research Institute · PHThe University of Queensland · AUUniversity of Oxford · GB

Funding

NSF | Directorate for Biological Sciences (BIO) IOS-1444511
6 · The paper itself

Abstract

As sequencing and genotyping technologies evolve, crop genetics researchers accumulate increasing numbers of genomic data sets from various genotyping platforms on different germplasm panels. Imputation is an effective approach to increase marker density of existing data sets toward the goal of integrating resources for downstream applications. While a number of imputation software packages are available, the limitations to utilization for the rice community include high computational demand and lack of a reference panel. To address these challenges, we develop the Rice Imputation Server, a publicly available web application leveraging genetic information from a globally diverse rice reference panel assembled here. This resource allows researchers to benefit from increased marker density without needing to perform imputation on their own machines. We demonstrate improvements that imputed data provide to rice genome-wide association (GWA) results of grain amylose content and show that the major functional nucleotide polymorphism is tagged only in the imputed data set.

Indexed as

Gene FrequencyGenome-Wide Association StudyGenotypeOryzaPolymorphism, Single Nucleotide

Identifiers

PMID30158584
PMCPMC6115364
OpenAlexW2888580500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.