Evidence map›Paper›PMID 30158553›Full record

ArticleScientific reports2018

Weighted Stochastic Block Models of the Human Connectome across the Life Span.

Joshua Faskowitz, Xiaoran Yan, Xi-Nian Zuo, Olaf Sporns

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Null models for lesion network mapping.Nature neuroscience · 2026
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  9. Sex-specific topological structure associated with dementia via latent space estimation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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  12. Hierarchical communities in the larvalProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  15. A generative model of the connectome with dynamic axon growth.bioRxiv : the preprint server for biology · 2024
    Article
  16. Article
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  18. A generative model of the connectome with dynamic axon growth.Network neuroscience (Cambridge, Mass.) · 2024
    Article
  19. Brain tumour genetic network signatures of survival.Brain : a journal of neurology · 2023
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  20. Graph lesion-deficit mapping of fluid intelligence.Brain : a journal of neurology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joshua FaskowitzProgram in Neuroscience, Indiana University, Bloomington, IN, USA.ORCID 0000-0003-1814-7206
Xiaoran YanIndiana University Network Science Institute, Indiana University, Bloomington, IN, USA.
Xi-Nian ZuoCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Olaf SpornsProgram in Neuroscience, Indiana University, Bloomington, IN, USA. osporns@indiana.edu.

Funding

CRCNS: Linking connectomic and large-Scale Dynamics of the Human BrainR01AT009036 · NCCIH · TRUSTEES OF INDIANA UNIVERSITY · PI SPORNS, OLAF · 2015 to 2017
$443k
National Natural Science Foundation of China (National Science Foundation of China) 81220108014National Science Foundation (NSF) 1342962NCCIH NIH HHS R01 AT009036U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 AT009036-01
6 · The paper itself

Abstract

The human brain can be described as a complex network of anatomical connections between distinct areas, referred to as the human connectome. Fundamental characteristics of connectome organization can be revealed using the tools of network science and graph theory. Of particular interest is the network's community structure, commonly identified by modularity maximization, where communities are conceptualized as densely intra-connected and sparsely inter-connected. Here we adopt a generative modeling approach called weighted stochastic block models (WSBM) that can describe a wider range of community structure topologies by explicitly considering patterned interactions between communities. We apply this method to the study of changes in the human connectome that occur across the life span (between 6-85 years old). We find that WSBM communities exhibit greater hemispheric symmetry and are spatially less compact than those derived from modularity maximization. We identify several network blocks that exhibit significant linear and non-linear changes across age, with the most significant changes involving subregions of prefrontal cortex. Overall, we show that the WSBM generative modeling approach can be an effective tool for describing types of community structure in brain networks that go beyond modularity.

Indexed as

ConnectomeModels, NeurologicalAdolescentAdultAgedAged, 80 and overAge FactorsBrainChildFemaleHumansMaleMiddle AgedYoung Adult

Identifiers

PMID30158553
PMCPMC6115421

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.