Evidence map›Paper›PMID 30158487›Full record

ArticleMolecules (Basel, Switzerland)2018

Development of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-

Florence Couly, Marine Harari, Carole Dubouilh-Benard, Laetitia Bailly, Emilie Petit, Julien Diharce, Pascal Bonnet, Laurent Meijer, Corinne Fruit, Thierry Besson

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. 29th Annual GP2A Medicinal Chemistry Conference.Pharmaceuticals (Basel, Switzerland) · 2021
    Article
  2. Article
  3. Alkaloid Enantiomers from the Roots ofMolecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Florence CoulyNormandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France. florence.couly@insa-rouen.fr.
Marine HarariNormandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France. marine.harari@etu.univ-rouen.fr.
Carole Dubouilh-BenardNormandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France. carole.dubouilh@univ-rouen.fr.
Laetitia BaillyNormandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France. laetitia.bailly@insa-rouen.fr.
Emilie PetitNormandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France. emilie.petit@insa-rouen.fr.
Julien DiharceInstitut de Chimie Organique et Analytique (ICOA), Université d'Orléans, UMR CNRS, 7311 BP 6759, 45067 Orléans CEDEX 2, France. julien.diharce@univ-orleans.fr.
Pascal BonnetInstitut de Chimie Organique et Analytique (ICOA), Université d'Orléans, UMR CNRS, 7311 BP 6759, 45067 Orléans CEDEX 2, France. pascal.bonnet@univ-orleans.fr.ORCID 0000-0001-6485-138X
Laurent MeijerManRos Therapeutics, Perharidy Peninsula, 29680 Roscoff, France. meijer@manros-therapeutics.com.ORCID 0000-0003-3511-4916
Corinne FruitNormandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France. corinne.fruit@univ-rouen.fr.ORCID 0000-0002-2878-4885
Thierry BessonNormandie University, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France. thierry.besson@univ-rouen.fr.ORCID 0000-0003-3025-6659

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efficient metal catalyzed C⁻H arylation of 8-alkyl-thiazolo[5,4-

Indexed as

Dyrk KinasesMicrowavesModels, MolecularMolecular Docking SimulationMolecular StructureProtein Kinase InhibitorsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesQuinazolinesStructure-Activity RelationshipDyrk KinasesProtein Kinase InhibitorsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesQuinazolinesCDK5C–H arylationCK1CLK1DYRK1AGSK-3microwave-assisted synthesisprotein kinasesthiazolo[5,4-f]quinazolin-9(8H)-ones

Identifiers

PMID30158487
PMCPMC6225322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.