Evidence map›Paper›PMID 30158463›Full record

ArticleBiomolecules2018

Predicting Aromatic Amine Mutagenicity with Confidence: A Case Study Using Conformal Prediction.

Ulf Norinder, Glenn Myatt, Ernst Ahlberg

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A local QSAR model based on the stability of nitrenium ions to support the ICH M7 expert review on the mutagenicity of primary aromatic amines.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2022
    Article
  5. Article
  6. A deep neural network-based approach for prediction of mutagenicity of compounds.Environmental science and pollution research international · 2021
    Article
  7. Machine Learning Strategies When Transitioning between Biological Assays.Journal of chemical information and modeling · 2021
    Article
  8. CombiningChemical research in toxicology · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Ulf NorinderSwetox, Karolinska Institutet, Unit of Toxicology Sciences, SE-151 36 Södertälje, Sweden. ulf.norinder@swetox.se.ORCID 0000-0003-3107-331X
Glenn MyattLeadscope, 1393 Dublin Road, Columbus, OH 43215, USA. gmyatt@leadscope.com.
Ernst AhlbergDrug Safety and Metabolism, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, SE-431 83 Mölndal, Sweden. Ernst.AhlbergHelgee@astrazeneca.com.
AstraZeneca (Sweden) · SELeadScope (United States) · USStockholm University · SE

Funding

Rapid response toxicology prediction platformR44ES026909 · NIEHS · LEADSCOPE, INC. · PI MYATT, GLENN JOHN · 2018 to 2019
$1000k
NIEHS NIH HHS R44 ES026909
6 · The paper itself

Abstract

The occurrence of mutagenicity in primary aromatic amines has been investigated using conformal prediction. The results of the investigation show that it is possible to develop mathematically proven

Indexed as

Molecular ConformationQuantitative Structure-Activity RelationshipAminesMutagensAminesMutagensaromatic aminesconfidenceconformal predictionmutagenicityrandom forest

Identifiers

PMID30158463
PMCPMC6163496
OpenAlexW2888802689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.