Evidence map›Paper›PMID 30158437›Full record

ArticleViruses2018

The Virology of Taterapox Virus In Vitro.

Scott Parker, Leonardo Camilo de Oliveira, Elliot J Lefkowitz, Robert Curtis Hendrickson, Cláudio A Bonjardim, William S M Wold, Hollyce Hartzler, Ryan Crump, Robert Mark Buller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Cell Cultures for Virology: Usability, Advantages, and Prospects.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Scott ParkerDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA. scott9379@gmail.com.ORCID 0000-0002-1079-0988
Leonardo Camilo de OliveiraGrupo de Transdução de Sinal do Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, Brazil. deolive2@gmail.com.
Elliot J LefkowitzDepartment of Microbiology, BBRB 276/11, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ElliotL@uab.edu.
Robert Curtis HendricksonDepartment of Microbiology, BBRB 276/11, University of Alabama at Birmingham, Birmingham, AL 35294, USA. curtish@uab.edu.
Cláudio A BonjardimGrupo de Transdução de Sinal do Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, Brazil. bonjardim@icb.ufmg.br.
William S M WoldDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA. bill.wold@health.slu.edu.
Hollyce HartzlerDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA. hollyce@gmail.com.
Ryan CrumpDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA. rcrump1313@gmail.com.
Robert Mark BullerDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Boulevard, St. Louis, MO 63104, USA. rcrump1313@gmail.com.
Saint Louis University · USUniversidade Federal de Minas Gerais · BRUniversity of Alabama at Birmingham · US

Funding

NIH HHS HHSN266200400036CNIH HHS U01 A15436
6 · The paper itself

Abstract

Taterapox virus (TATV) is phylogenetically the closest related virus to variola-the etiological agent of smallpox. Despite the similarity, few studies have evaluated the virus. In vivo, TATV can infect several animals but produces an inapparent infection in wild-type mice; however, TATV does cause morbidity and mortality in some immunocompromised strains. We employed in vitro techniques to compare TATV to ectromelia (ECTV) and vaccinia (VACV) viruses. Both ECTV and TATV replicate efficiently in primate cell lines but TATV replicates poorly in murine cells lines. Furthermore, TATV induces cytopathic effects, but to a lesser extent than ECTV, and changes cytoskeletal networks differently than both ECTV and VACV. Bioinformatic studies revealed differences in several immunomodulator open reading frames that could contribute to the reduced virulence of TATV, which were supported by in vitro cytokine assays.

Indexed as

A549 CellsAnimalsCell LineChlorocebus aethiopsCowpox virusEctromelia virusHumansMiceMice, Inbred BALB COpen Reading FramesOrthopoxvirusPhylogenyPoxviridae InfectionsSequence Analysis, ProteinSpleenVaccinia virusectromeliagerbilorthopoxvirussmallpoxtaterapoxvacciniavariola

Identifiers

PMID30158437
PMCPMC6163509
OpenAlexW2889452879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.