Evidence map›Paper›PMID 30158246›Full record

ArticleThe Journal of biological chemistry2018

Copper regulates the interactions of antimicrobial piscidin peptides from fish mast cells with formyl peptide receptors and heparin.

So Young Kim, Fuming Zhang, Wanghua Gong, Keqiang Chen, Kai Xia, Fei Liu, Richard Gross, Ji Ming Wang, Robert J Linhardt, Myriam L Cotten

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

So Young KimFrom the Biochemistry and Biophysics Graduate Program.
Fuming ZhangDepartments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering, and Biomedical Engineering, and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, zhangf2@rpi.edu.
Wanghua Gongthe Basic Research Program, Leidos Biomedical Research, Inc., Frederick, Maryland 21702.
Keqiang Chenthe Cancer and Inflammation Program, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, and.
Kai XiaDepartments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering, and Biomedical Engineering, and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180.
Fei LiuDepartments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering, and Biomedical Engineering, and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180.
Richard GrossDepartments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering, and Biomedical Engineering, and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180.
Ji Ming Wangthe Cancer and Inflammation Program, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, and.
Robert J LinhardtFrom the Biochemistry and Biophysics Graduate Program, linhar@rpi.edu.
Myriam L Cottenthe Department of Applied Science, College of William and Mary, Williamsburg, Virginia 23185 mcotten@wm.edu.ORCID 0000-0002-6732-1736
Rensselaer Polytechnic Institute · USCenter for Cancer Research · USLeidos Biomedical Research Inc. (United States)Williams (United States) · US

Funding

The Role of Cellular Receptors Involved in Inflammation and Tumor ProgressionZIABC010015 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, JI MING · 2009 to 2023
$6.3M
Endothelial glycocalyx reconstitution during sepsisR01HL125371 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI LINHARDT, ROBERT J, SCHMIDT, ERIC PETER · 2014 to 2018
$3.4M
The role ofglycosaminoglycan N-sulfation in glomerular biology/pathobiologyR01DK111958 · NIDDK · LOUISIANA STATE UNIV HSC SHREVEPORT · PI MCCARTHY, KEVIN JOHN · 2017 to 2021
$2.6M
Uncovering the controlling mechanisms in heparan sulfate biosynthesisU01GM102137 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIAN · 2013 to 2016
$1.2M
NHLBI NIH HHS R01 HL125371NIDDK NIH HHS R01 DK111958NIGMS NIH HHS U01 GM102137
6 · The paper itself

Abstract

Phagocytic cells in fish secrete antimicrobial peptides (AMPs) such as piscidins, glycosaminoglycans such as heparin, and copper ions as first-line immune defenses. Recently, we established that Cu

Indexed as

Amino Acid SequenceAnimalsAnti-Infective AgentsAntimicrobial Cationic PeptidesBassBone Marrow CellsChemotaxisCoordination ComplexesCopperFish ProteinsHEK293 CellsHeparinHumansImmunity, InnateMast CellsMiceAnti-Infective AgentsAntimicrobial Cationic PeptidesCoordination ComplexesCopperFish Proteinsformyl peptide receptor 2, mouseFpr1 protein, mouseHeparinmoronecidin protein, Morone saxatilisProtein IsoformsReceptors, Formyl Peptideantimicrobial peptide (AMP)chemotaxiscopperformyl peptide receptorsglycosaminoglycanheparinhistidinehost defensepiscidinsurface plasmon resonance (SPR)

Identifiers

PMID30158246
PMCPMC6177607
OpenAlexW2889224376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.