Evidence map›Paper›PMID 30158242›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2018

A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo.

Luisa L Scott, Sangeetha Iyer, Ashley E Philpo, Melva N Avalos, Natalie S Wu, Ted Shi, Brooke A Prakash, Thanh-Tu Nguyen, S John Mihic, Richard W Aldrich and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Natural variation in protein kinase D modifies alcohol sensitivity inbioRxiv : the preprint server for biology · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Luisa L ScottWaggoner Center for Alcohol and Addiction Research (L.L.S., S.I., A.E.P., M.N.A., N.S.W., T.S., B.A.P., T.-T.N., S.J.M., R.W.A., J.T.P.), Department of Neuroscience (S.J.M., R.W.A., J.T.P.), and Center for Learning and Memory (R.W.A., J.T.P.), The University of Texas at Austin, Austin, Texas jonps@austin.utexas.edu luisa_scott@utexas.edu.ORCID 0000-0003-4518-7094
Sangeetha IyerWaggoner Center for Alcohol and Addiction Research (L.L.S., S.I., A.E.P., M.N.A., N.S.W., T.S., B.A.P., T.-T.N., S.J.M., R.W.A., J.T.P.), Department of Neuroscience (S.J.M., R.W.A., J.T.P.), and Center for Learning and Memory (R.W.A., J.T.P.), The University of Texas at Austin, Austin, Texas.
Ashley E PhilpoWaggoner Center for Alcohol and Addiction Research (L.L.S., S.I., A.E.P., M.N.A., N.S.W., T.S., B.A.P., T.-T.N., S.J.M., R.W.A., J.T.P.), Department of Neuroscience (S.J.M., R.W.A., J.T.P.), and Center for Learning and Memory (R.W.A., J.T.P.), The University of Texas at Austin, Austin, Texas.
Melva N AvalosWaggoner Center for Alcohol and Addiction Research (L.L.S., S.I., A.E.P., M.N.A., N.S.W., T.S., B.A.P., T.-T.N., S.J.M., R.W.A., J.T.P.), Department of Neuroscience (S.J.M., R.W.A., J.T.P.), and Center for Learning and Memory (R.W.A., J.T.P.), The University of Texas at Austin, Austin, Texas.
Natalie S WuWaggoner Center for Alcohol and Addiction Research (L.L.S., S.I., A.E.P., M.N.A., N.S.W., T.S., B.A.P., T.-T.N., S.J.M., R.W.A., J.T.P.), Department of Neuroscience (S.J.M., R.W.A., J.T.P.), and Center for Learning and Memory (R.W.A., J.T.P.), The University of Texas at Austin, Austin, Texas.
Ted ShiWaggoner Center for Alcohol and Addiction Research (L.L.S., S.I., A.E.P., M.N.A., N.S.W., T.S., B.A.P., T.-T.N., S.J.M., R.W.A., J.T.P.), Department of Neuroscience (S.J.M., R.W.A., J.T.P.), and Center for Learning and Memory (R.W.A., J.T.P.), The University of Texas at Austin, Austin, Texas.ORCID 0000-0002-8055-0955
Brooke A PrakashWaggoner Center for Alcohol and Addiction Research (L.L.S., S.I., A.E.P., M.N.A., N.S.W., T.S., B.A.P., T.-T.N., S.J.M., R.W.A., J.T.P.), Department of Neuroscience (S.J.M., R.W.A., J.T.P.), and Center for Learning and Memory (R.W.A., J.T.P.), The University of Texas at Austin, Austin, Texas.
Thanh-Tu NguyenWaggoner Center for Alcohol and Addiction Research (L.L.S., S.I., A.E.P., M.N.A., N.S.W., T.S., B.A.P., T.-T.N., S.J.M., R.W.A., J.T.P.), Department of Neuroscience (S.J.M., R.W.A., J.T.P.), and Center for Learning and Memory (R.W.A., J.T.P.), The University of Texas at Austin, Austin, Texas.
S John MihicWaggoner Center for Alcohol and Addiction Research (L.L.S., S.I., A.E.P., M.N.A., N.S.W., T.S., B.A.P., T.-T.N., S.J.M., R.W.A., J.T.P.), Department of Neuroscience (S.J.M., R.W.A., J.T.P.), and Center for Learning and Memory (R.W.A., J.T.P.), The University of Texas at Austin, Austin, Texas.
Richard W AldrichWaggoner Center for Alcohol and Addiction Research (L.L.S., S.I., A.E.P., M.N.A., N.S.W., T.S., B.A.P., T.-T.N., S.J.M., R.W.A., J.T.P.), Department of Neuroscience (S.J.M., R.W.A., J.T.P.), and Center for Learning and Memory (R.W.A., J.T.P.), The University of Texas at Austin, Austin, Texas.
Jonathan T PierceWaggoner Center for Alcohol and Addiction Research (L.L.S., S.I., A.E.P., M.N.A., N.S.W., T.S., B.A.P., T.-T.N., S.J.M., R.W.A., J.T.P.), Department of Neuroscience (S.J.M., R.W.A., J.T.P.), and Center for Learning and Memory (R.W.A., J.T.P.), The University of Texas at Austin, Austin, Texas jonps@austin.utexas.edu luisa_scott@utexas.edu.
The University of Texas at Austin · USHesco (United States) · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Novel molecular and cellular approaches for alcoholism medication developmentP01AA020683 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI MIHIC, S JOHN · 2012 to 2016
$3.3M
A screen for peptides that alter BK channel-mediated alcohol intoxicationR01AA020992 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI ALDRICH, RICHARD, MIHIC, S JOHN · 2012 to 2016
$2.0M
Ethanol action through the BK potassium channelF32AA014313 · NIAAA · ERNEST GALLO CLINIC AND RESEARCH CENTER · PI PIERCE-SHIMOMURA, JONATHAN T · 2003 to 2005
$131k
NIAAA NIH HHS F32 AA014313NIAAA NIH HHS P01 AA020683NIAAA NIH HHS R01 AA020992NIH HHS P40 OD010440
6 · The paper itself

Abstract

Alcohol is a widely used and abused substance. A major unresolved issue in the alcohol research field is determining which of the many alcohol target proteins identified to date is responsible for shaping each specific alcohol-related behavior. The large-conductance, calcium- and voltage-activated potassium channel (BK channel) is a conserved target of ethanol. Genetic manipulation of the highly conserved BK

Indexed as

AlcoholismAnimalsCaenorhabditis elegansCell LineEthanolHEK293 CellsHumansLarge-Conductance Calcium-Activated Potassium ChannelsNeuronsPeptidesXenopusEthanolLarge-Conductance Calcium-Activated Potassium ChannelsPeptides

Identifiers

PMID30158242
PMCPMC6178125
OpenAlexW2889246369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.