Evidence map›Paper›PMID 30158195›Full record

ArticleJournal of clinical microbiology2018

Ultrasensitive Detection of Clostridioides difficile Toxins A and B by Use of Automated Single-Molecule Counting Technology.

Johanna Sandlund, Amelita Bartolome, Anna Almazan, Stanley Tam, Sheryl Biscocho, Salina Abusali, Jeffrey J Bishop, Niamh Nolan, Joel Estis, John Todd and 3 more

Open access · bronzeAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026
    Review
  3. Diagnosis ofJournal of medical microbiology · 2024
    Review
  4. Emerging Diagnostics inInternational journal of molecular sciences · 2024
    Review
  5. Rapid Quantification ofAnalytical chemistry · 2022
    Article
  6. Review
  7. DiscordantBMJ open · 2020
    Article
  8. Hindsight Is 2019-the Year in Clinical Microbiology.Clinical microbiology newsletter · 2020
    Article
  9. Review
  10. Article
  11. The Role of Diagnostic Stewardship inCurrent infectious disease reports · 2020
    Article
  12. Article
  13. South African Society of Clinical MicrobiologySouthern African journal of infectious diseases · 2020
    Article
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Review
  19. Therapeutic advances in infectious disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Johanna SandlundSingulex, Inc., Alameda, California, USA j.sandlund@singulex.com.
Amelita BartolomeSingulex, Inc., Alameda, California, USA.
Anna AlmazanSingulex, Inc., Alameda, California, USA.
Stanley TamSingulex, Inc., Alameda, California, USA.
Sheryl BiscochoSingulex, Inc., Alameda, California, USA.
Salina AbusaliSingulex, Inc., Alameda, California, USA.
Jeffrey J BishopSingulex, Inc., Alameda, California, USA.
Niamh NolanSingulex, Inc., Alameda, California, USA.
Joel EstisSingulex, Inc., Alameda, California, USA.
John ToddSingulex, Inc., Alameda, California, USA.
Stephen YoungTriCore Reference Laboratories, Albuquerque, New Mexico, USA.
Fiona SenchynaDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Niaz BanaeiDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Stanford University · USApplied Research Associates (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current tests for the detection of

Indexed as

Automation, LaboratoryBacterial ProteinsBacterial ToxinsBacteriological TechniquesClostridioides difficileClostridium InfectionsEnterotoxinsFecesFemaleHumansImmunoassayMalePolymerase Chain ReactionReproducibility of ResultsSensitivity and SpecificityBacterial ProteinsBacterial ToxinsEnterotoxinstcdA protein, Clostridium difficiletoxB protein, Clostridium difficileC. difficilesingle-molecule counting technologyultrasensitivity

Identifiers

PMID30158195
PMCPMC6204678
OpenAlexW2888954543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.