ArticleJournal of immunology (Baltimore, Md. : 1950)2018
Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A.
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Serum amyloid A: multifaceted roles in inflammation and cellular interactions.Immunologic research · 2025Review
- Serum Amyloid A: A Double-Edged Sword in Health and Disease.International journal of molecular sciences · 2025Review
- Functional Interactions Between Recombinant Serum Amyloid A1 (SAA1) and Chemokines in Leukocyte Recruitment.International journal of molecular sciences · 2025Review
- Recent Advances in Studies of Serum Amyloid A: Implications in Inflammation, Immunity and Tumor Metastasis.International journal of molecular sciences · 2025Review
- Immuno-protective impact and clinical translation of radioprotective agents in cancer radiotherapy.Frontiers in immunology · 2025Review
- Interactions of Serum Amyloid A Proteins with the Blood-Brain Barrier: Implications for Central Nervous System Disease.International journal of molecular sciences · 2024Review
- Acute-serum amyloid A and A-SAA-derived peptides as formyl peptide receptor (FPR) 2 ligands.Frontiers in endocrinology · 2023Review
- Effects of serum amyloid protein A on influenza A virus replication and viral interactions with neutrophils.Journal of leukocyte biology · 2021Article
- Review
- A Cross-Sectional and Longitudinal Study to Define Alarmins and A-SAA Variants as Companion Markers in Early Rheumatoid Arthritis.Frontiers in immunology · 2021Article
- Serum amyloid A is a positive acute phase protein in Russian sturgeon challenged with Aeromonas hydrophila.Scientific reports · 2020Article
- Royal Jelly as an Intelligent Anti-Aging Agent-A Focus on Cognitive Aging and Alzheimer's Disease: A Review.Antioxidants (Basel, Switzerland) · 2020Review
- Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve.Current atherosclerosis reports · 2020Review
- [Association of rs4638289 and rs7131332 polymorphisms of the serum amyloid A1 gene with Kawasaki disease].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Biological Characterization of Commercial Recombinantly Expressed Immunomodulating Proteins Contaminated with Bacterial Products in the Year 2020: The SAA3 Case.Mediators of inflammation · 2020Article
- Article
- Serum Amyloid A1 (SAA1) Revisited: Restricted Leukocyte-Activating Properties of Homogeneous SAA1.Frontiers in immunology · 2020Article
- Role of serum amyloid A in atherosclerosis.Current opinion in lipidology · 2019Review
- Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet.Frontiers in immunology · 2019Article
- Serum Amyloid A3 is required for normal lung development and survival following influenza infection.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Edward J BurgessVermont Lung Center, University of Vermont, Burlington, VT 05405.
Laura R HoytVermont Lung Center, University of Vermont, Burlington, VT 05405.ORCID 0000-0002-0350-4154
Matthew J RandallVermont Lung Center, University of Vermont, Burlington, VT 05405.ORCID 0000-0003-3840-8952
Madeleine M MankVermont Lung Center, University of Vermont, Burlington, VT 05405.ORCID 0000-0002-0617-4736
Joseph J BivonaVermont Lung Center, University of Vermont, Burlington, VT 05405.
Philip L EisenhauerImmunobiology Division, Department of Medicine, University of Vermont, Burlington, VT 05405.
Jason W BottenVermont Lung Center, University of Vermont, Burlington, VT 05405.
Bryan A BallifDepartment of Biology, University of Vermont, Burlington, VT 05405; and.
Ying-Wai LamDepartment of Biology, University of Vermont, Burlington, VT 05405; and.
Matthew J WargoVermont Lung Center, University of Vermont, Burlington, VT 05405.ORCID 0000-0001-5659-749X
Jonathan E BoysonVermont Lung Center, University of Vermont, Burlington, VT 05405.ORCID 0000-0003-2673-9148
Jennifer L AtherVermont Lung Center, University of Vermont, Burlington, VT 05405.
Matthew E PoynterVermont Lung Center, University of Vermont, Burlington, VT 05405; matthew.poynter@med.uvm.edu.
University of Vermont · US
Funding
Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI CHRISTOPHER S FRANCKLYN · 2012 to 2026
$58.4MVERMONT IMMUNOBIOLOIGY/ INFECTIOUS DISEASES CENTERP20RR021905 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MATTHEWS, DWIGHT E · 2006 to 2011
$14.5MVermont Immunobioloigy/ Infectious Diseases CenterP20GM103496 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2012 to 2015
$8.7MVermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8MMultidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1MObese Allergic Asthma and the Impact of Weight Loss on Airway Epithelial FunctionR01HL133920 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI DIXON, ANNE E, POYNTER, MATTHEW E · 2016 to 2020
$3.9MTranslational Research in Lung Biology and DiseaseP30GM103532 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI IRVIN, CHARLES G · 2012 to 2016
$3.7MKetone Body Supplementation in Obese AsthmaR01HL142081 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI POYNTER, MATTHEW E · 2018 to 2021
$1.8MSerum Amyloid A3 in Allergic Asthma: An Endogenous Mediator of Disease SeverityR01HL107291 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI POYNTER, MATTHEW E · 2012 to 2015
$1.5MPseudomonas detection and metabolism of sphingosineR01AI103003 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI WARGO, MATTHEW J · 2013 to 2017
$1.4MNCRR NIH HHS P20 RR021905NHLBI NIH HHS R01 HL107291NHLBI NIH HHS R01 HL133920NHLBI NIH HHS R01 HL142081NHLBI NIH HHS T32 HL076122NIAID NIH HHS R01 AI103003NIGMS NIH HHS P20 GM103449NIGMS NIH HHS P20 GM103496NIGMS NIH HHS P30 GM103532NIGMS NIH HHS P30 GM118228
Abstract
Studies comparing endogenous and recombinant serum amyloid A (SAA) have generated conflicting data on the proinflammatory function of these proteins. In exploring this discrepancy, we found that in contrast to commercially sourced recombinant human SAA1 (hSAA1) proteins produced in
Indexed as
AdultAnimalsCell DifferentiationCytokinesEscherichia coliEscherichia coli ProteinsHEK293 CellsHumansInflammation MediatorsLeukocytes, MononuclearLipoproteinsLymphocyte ActivationMiceMice, Inbred C57BLRecombinant ProteinsSerum Amyloid A ProteinCytokinesEscherichia coli ProteinsInflammation MediatorsLipoproteinsRecombinant ProteinsSerum Amyloid A ProteinTLR2 protein, humanToll-Like Receptor 2
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.