Evidence map›Paper›PMID 30157911›Full record

Trial reportArthritis research & therapy2018

Physical activity is related to function and fatigue but not pain in women with fibromyalgia: baseline analyses from the Fibromyalgia Activity Study with TENS (FAST).

Ericka N Merriwether, Laura A Frey-Law, Barbara A Rakel, Miriam B Zimmerman, Dana L Dailey, Carol G T Vance, Meenakshi Golchha, Katherine M Geasland, Ruth Chimenti, Leslie J Crofford and 1 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01888640 (Fibromyalgia Activity Study With Transcutaneous Electrical Nerve Stimulation), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01888640 nacompletednot on this map

Fibromyalgia Activity Study With Transcutaneous Electrical Nerve Stimulation

TypeinterventionalSponsorKathleen SlukaRan2013 to 2018Enrolled301ConditionsFibromyalgiaArmsTENS
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Do Physical Activities Prevent the Occurrence of Bothersome Pain?Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025
    Article
  7. Review
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Physical Conditioning, Obesity and Fibromyalgia: Causal Relationship or Confounding?Principles and practice of clinical research (2015) · 2023
    Article
  13. Review
  14. Article
  15. Functional and psychosocial impact of COVID-19 pandemic on rheumatic patients' quality of life in Saudi Arabia.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Article
  16. Article
  17. Article
  18. The Role of Walking in the Relationship between Catastrophizing and Fatigue in Women with Fibromyalgia.International journal of environmental research and public health · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ericka N MerriwetherDepartment of Physical Therapy, Steinhardt School of Culture, Education, and Human Development, New York University, New York, NY, USA.
Laura A Frey-LawDepartment of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA.
Barbara A RakelCollege of Nursing, University of Iowa, Iowa City, IA, USA.
Miriam B ZimmermanCollege of Public Health, University of Iowa, Iowa City, IA, USA.
Dana L DaileyDepartment of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA.
Carol G T VanceDepartment of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA.
Meenakshi GolchhaDepartment of Medicine/Rheumatology & Immunology, Vanderbilt University, Nashville, TN, USA.
Katherine M GeaslandDepartment of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA.
Ruth ChimentiDepartment of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA.
Leslie J CroffordDepartment of Medicine/Rheumatology & Immunology, Vanderbilt University, Nashville, TN, USA.
Kathleen A SlukaDepartment of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA. kathleen-sluka@uiowa.edu.
University of Iowa · USVanderbilt University · USNew York University · US

Funding

The University of Iowa Clinical and Translational Science AwardU54TR001356 · NCATS · UNIVERSITY OF IOWA · PI WINOKUR, PATRICIA · 2015 to 2016
$7.1M
University of Iowa Institute for Clinical and Translational ScienceU54TR001013 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2014 to 2014
$4.2M
Interdisciplinary Training Program in Pain ResearchT32NS045549 · NINDS · UNIVERSITY OF IOWA · PI KATHLEEN A SLUKA, Yuriy M Usachev · 2004 to 2026
$3.7M
Mechanism-based treatment approach to chronic tendinopathy painR00AR071517 · NIAMS · UNIVERSITY OF IOWA · PI CHIMENTI, RUTH LOUISE PORTER · 2019 to 2021
$740k
Mechanism-based treatment approach to chronic tendinopathy painK99AR071517 · NIAMS · UNIVERSITY OF IOWA · PI CHIMENTI, RUTH LOUISE PORTER · 2017 to 2018
$172k
NCATS NIH HHS U54 TR001013NCATS NIH HHS U54 TR001356NIAMS NIH HHS K99 AR071517NIAMS NIH HHS R00 AR071517NIH HHS UM1 AR06338
6 · The paper itself

Abstract

backgroundAlthough exercise is an effective treatment for fibromyalgia, the relationships between lifestyle physical activity and multiple symptomology domains of fibromyalgia are not clear. Thus, the purpose of this study was to comprehensively examine the relationships between lifestyle physical activity with multiple outcome domains in women with fibromyalgia, including pain, fatigue, function, pain-related psychological constructs, and quality of life.

methodsWomen (N = 171), aged 20 to 70 years, diagnosed with fibromyalgia, recruited from an ongoing two-site clinical trial were included in this prespecified subgroup analysis of baseline data. Physical activity was assessed using self-report and accelerometry. Symptomology was assessed using questionnaires of perceived physical function, quality of life, fatigue, pain intensity and interference, disease impact, pain catastrophizing, and fear of movement. In addition, quantitative sensory testing of pain sensitivity and performance-based physical function were assessed. Correlation coefficients, regression analyses and between-group differences in symptomology by activity level were assessed, controlling for age and body mass index (BMI).

resultsLifestyle physical activity was most closely associated with select measures of physical function and fatigue, regardless of age and BMI. Those who performed the lowest levels of lifestyle physical activity had poorer functional outcomes and greater fatigue than those with higher physical activity participation. No relationships between lifestyle physical activity and pain, pain sensitivity, or pain-related psychological constructs were observed.

conclusionsLifestyle physical activity is not equally related to all aspects of fibromyalgia symptomology. Lifestyle physical activity levels have the strongest correlations with function, physical quality of life, and movement fatigue in women with fibromyalgia. No relationships between lifestyle physical activity and pain, pain sensitivity, or psychological constructs were observed. These data suggest that physical activity levels are more likely to affect function and fatigue, but have negligible relationships with pain and pain-related psychological constructs, in women with fibromyalgia.

trial registrationClinicalTrials.gov, NCT01888640 . Registered on 28 June 2013.

Indexed as

AdultAgedDouble-Blind MethodExerciseFatigueFemaleFibromyalgiaHumansMiddle AgedPainPain MeasurementQuality of LifeSurveys and QuestionnairesTranscutaneous Electric Nerve StimulationTreatment OutcomeYoung AdultAccelerometryActiGraphFatigueFibromyalgiaFunctionIPAQPainPROMIS

Identifiers

PMID30157911
PMCPMC6116369
OpenAlexW2889103490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.