Evidence map›Paper›PMID 30157892›Full record

ArticleRadiation oncology (London, England)2018

Light and shadows of a new technique: is photon total-skin irradiation using helical IMRT feasible, less complex and as toxic as the electrons one?

Michela Buglione, Luigi Spiazzi, Mauro Urpis, Liliana Baushi, Rossella Avitabile, Nadia Pasinetti, Paolo Borghetti, Luca Triggiani, Sara Pedretti, Federica Saiani and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiation oncology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Total skin electron beam therapy.Frontiers in oncology · 2025
    Article
  2. Article
  3. Total Skin Treatment with Helical Arc Radiotherapy.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Michela BuglioneRadiation Oncology Department, University and Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy. michela.buglione@unibs.it.ORCID http://orcid.org/0000-0002-5485-1260
Luigi SpiazziMedical Physics, Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Mauro UrpisRadiation Oncology Department, University and Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Liliana BaushiRadiation Oncology Department, University and Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Rossella AvitabileMedical Physics, Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Nadia PasinettiRadiation Oncology Department, University and Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Paolo BorghettiRadiation Oncology Department, University and Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Luca TriggianiRadiation Oncology Department, University and Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Sara PedrettiRadiation Oncology Department, University and Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Federica SaianiMedical Physics, Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Alfredo FiumeMedical Physics, Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Diana GrecoRadiation Oncology Department, University and Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Stefano CiccarelliRadiation Oncology Department, University and Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Alessia PoloniniMedical Physics, Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Renzo MorettiMedical Physics, Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Stefano Maria MagriniRadiation Oncology Department, University and Spedali Civili Hospital - Brescia, P.le Spedali Civili 1 -, 25123, Brescia, Italy.
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiotherapy is one of the standard treatments for cutaneous lymphoma and Total Skin Electrons Beam Irradiation (TSEBI) is generally used to treat diffuse cutaneous lymphoma and some cases of localized disease. Helical IMRT (HI) allows to treat complex target with optimal dose distribution and organ at risk sparing, so helical tomotherapy has been proposed as alternative technique to TSEBI but only one preliminary report has been published.

methodsThree patients treated (from May 2013 to December 2014) with Helical IMRT, with a total dose between 24 and 30 Gy, were retrospectively evaluated. Data about dosimetric features, response and acute toxicity were registered and analyzed. Planned target coverage was compared with daily in vivo measures and dose calculation based on volumetric images used for set up evaluation as well.

resultsThe patients had a mean measured surface fraction dose ranging from 1.54 Gy up to 2.0 Gy. A planned target dose ranging from 85 to 120% of prescription doses was obtained. All doses to Organs At Risk were within the required constraints. Particular attention was posed on "whole bone marrow" planned V

conclusionBased on our limited results TSEBI should still be considered the standard method to treat total skin because of its pattern of acute and late toxicities and the dose distribution. In this particular case the better target coverage obtained with HI can be paid in terms of worse toxicity. Helical IMRT can instead be considered optimal in treating large, convex, cutaneous areas where it is difficult to use multiple electrons fields in relation with the clinical results and the limited and reversible toxicities.

Indexed as

ElectronsFeasibility StudiesFemaleHumansLymphoma, T-Cell, CutaneousMaleMycosis FungoidesOrgans at RiskPhotonsRadiotherapy DosageRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedReproducibility of ResultsRetrospective StudiesSkin NeoplasmsWhole-Body IrradiationBone marrowPhotonsPrimary cutaneous lymphoma (PCL)RadiotherapyTotal skin electrons beam irradiation - TSEBITotal skin irradiationToxicity

Identifiers

PMID30157892
PMCPMC6114532
OpenAlexW2888915115

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.