Evidence map›Paper›PMID 30157791›Full record

ArticleBMC neurology2018

Comparison of the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) during carotid artery stenting (CAS) and carotid endarterectomy (CEA).

Ákos Mérei, Bálint Nagy, Gábor Woth, János Lantos, Ferenc Kövér, Lajos Bogár, Diána Mühl

Registry-linked trialOpen access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03410576 (Comparison of the Perioperative Time Course of Matrix Metalloproteinase-9), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03410576 completednot on this map

Comparison of the Perioperative Time Course of Matrix Metalloproteinase-9 (MMP-9) and Its Inhibitor (TIMP-1) During Carotid Artery Stenting (CAS) and Carotid Endarterectomy (CEA)

TypeobservationalSponsorUniversity of PecsRan2013 to 2015Enrolled25ConditionsCarotid Stenosis, Ischemia Reperfusion InjuryArmsCarotid artery stenting, Carotid endarterectomy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ákos MéreiDepartment of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs, Ifjúság Str. 13, Pécs, HU-7624, Hungary. merei.akos@gmail.com.ORCID http://orcid.org/0000-0002-0317-3543
Bálint NagyDepartment of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs, Ifjúság Str. 13, Pécs, HU-7624, Hungary.
Gábor WothDepartment of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs, Ifjúság Str. 13, Pécs, HU-7624, Hungary.
János LantosDepartment of Surgical Research and Techniques, Medical School, University of Pécs, Szigeti Str. 12, Pécs, HU-7624, Hungary.
Ferenc KövérDepartment of Neurosurgery, Medical School, University of Pécs, Rét Str. 2, Pécs, HU-7623, Hungary.
Lajos BogárDepartment of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs, Ifjúság Str. 13, Pécs, HU-7624, Hungary.
Diána MühlDepartment of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs, Ifjúság Str. 13, Pécs, HU-7624, Hungary.
University of Pecs · HU

Funding

Higher Education Institutional Excellence Program of the Ministry of Human Capacities 20765-3/2018/FEKUTSTRAT at University of PécsPTE ÁOK-KA 2017-07
6 · The paper itself

Abstract

backgroundOur aim was to compare the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) in during carotid endarterectomy (CEA) and carotid artery stenting (CAS).

methodsIn our prospective study, twenty-five patients who were scheduled to undergo CAS were enrolled. We used a matched, historical CEA group as controls. Blood samples were collected at four time points: T1: preoperative; T2: 60 min after stent insertion; T3: first postoperative morning; and T4: third postoperative morning. Plasma MMP-9 and TIMP-1 levels were measured by ELISA.

resultsIn the CEA group, the plasma levels of MMP-9 were significantly elevated at T3 compared to T1. In the CAS group, there was no significant difference in MMP-9 levels in the perioperative period. MMP-9 levels were significantly higher in the T3 samples of the CEA group compared to the CAS group. Significantly lower TIMP-1 levels were measured in both groups at T2 than at T1 in both groups. MMP-9/TIMP-1 at T3 was significantly higher than that at T1 in the CEA group compared to both T1 and the CAS group.

conclusionsCAS triggers smaller changes in the MMP-9-TIMP-1 system during the perioperative period, which may correlate with a lower incidence of central nervous system complications. Additional studies as well as cognitive and functional surveys are warranted to determine the clinical relevance of our findings.

trial registrationNIH U.S. National Library of Medicine, Clinicaltrials.gov,NCT03410576, 24.01.2018, Retrospectively registered.

Indexed as

Endarterectomy, CarotidAgedCarotid StenosisFemaleHumansIncidenceMaleMatrix Metalloproteinase 9Middle AgedPerioperative PeriodProspective StudiesRetrospective StudiesStentsTime FactorsTissue Inhibitor of Metalloproteinase-1Treatment OutcomeMatrix Metalloproteinase 9MMP9 protein, humanTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1Carotid endarterectomyCarotid stentingMatrix metalloproteinaseMMP-9TIMP-1

Identifiers

PMID30157791
PMCPMC6114896
OpenAlexW2889157056

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.