ArticleBMC cardiovascular disorders2018
Effect of serum electrolytes within normal ranges on QTc prolongation: a cross-sectional study in a Chinese rural general population.
Article in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Assessment of Hypertension Using Clinical Electrocardiogram Features: A First-Ever Review.Frontiers in medicine · 2020Pooled it
- Sex differences in potassium regulation: evidence, molecular mechanisms and clinical implications.Biology of sex differences · 2026Review
- Article
- Differences in Cardiovascular, Biochemical and Nutritional Parameters Between High- and Low-Altitude Winter Sports Athletes.Nutrients · 2025Article
- Determinants of QTc Interval Prolongation in Patients with Hypopituitarism and Other Pituitary Disorders.Biomedicines · 2025Article
- Amiodarone Therapy: Updated Practical Insights.Journal of clinical medicine · 2024Review
- Life-Threatening Cardiac Arrhythmias in a Case of Undetected Myxedema Coma: Importance of Early Detection and Medication Adherence.The American journal of case reports · 2023Article
- Second to none: rationale, timing, and clinical management of clozapine use in schizophrenia.Therapeutic advances in psychopharmacology · 2023Review
- Prospective real-time evaluation of the QTc interval variation after low-dose droperidol among emergency department patients.The American journal of emergency medicine · 2022Observational
- Declining Levels and Bioavailability of IGF-I in Cardiovascular Aging Associate With QT Prolongation-Results From the 1946 British Birth Cohort.Frontiers in cardiovascular medicine · 2022Article
- How safe are children with COVID-19 from cardiac risks? Pediatric risk assesment; insights from echocardiography and electrocardiographyTurkish journal of medical sciences · 2021Article
- Predictive factors for cardiac conduction abnormalities with hydroxychloroquine-containing combinations for COVID-19.International journal of antimicrobial agents · 2020Article
- Cardiac workup and monitoring in hospitalised children with COVID- 19.Cardiology in the young · 2020Article
- Effect of Methadone or Hydromorphone on Cardiac Conductivity in Dogs Before and During Sevoflurane Anesthesia.Frontiers in veterinary science · 2020Article
- Acute effect of a peritoneal dialysis exchange on electrolyte concentration and QT interval in uraemic patients.Clinical and experimental nephrology · 2019Article
- A Prospective Observational Study in Adult Medical Intensive Care Unit Patients with Drug-Induced QTc with Correlation of Serum Potassium, Magnesium Level of Clinical Outcome.Journal of pharmacy & bioallied sciencesArticle
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMany previous clinical studies have reported that prolongation of the QT interval corrected for heart rate (QTc) is associated with an increased risk of sudden cardiac death and all-cause mortality. This study aimed to explore associations between serum electrolytes and QTc prolongation in the north-eastern Chinese rural general population.
methodsWe performed a cross-sectional study including 10,334 (4820 men and 5514 women) from the general population aged ≥35 years in the Liaoning Province from 2012 to 2013. Anthropometric measurements, laboratory examinations and self-reported lifestyle factor information, echocardiography and electrocardiogram were collected by trained personnel. The associations between serum electrolytes and QTc prolongation were tested using multiple linear regression and logistic regression analyses.
resultsThe mean QTc interval were 415.6 ± 18.8 and 470.1 ± 23.1 ms in normal group and QTc prolongation group respectively. The prevalence of QTc prolongation increased significantly with a decrease in serum potassium and an increase in magnesium. Stepwise multiple linear regression showed that age, hypertension, waist circumference were prominently positive associated with QTc interval both in male and female population. But serum potassium was significantly inversely associated with QTc interval. Serum magnesium and calcium also showed a positive relationship with QTc interval. Furthermore, multiple logistic regression found that lower quartile of serum potassium had higher risk for QTc prolongation, especially in female population (Q2 vs. Q4: OR: 1.54, 95%CI: 1.01-2.35; Q1 vs. Q4: OR: 2.02, 95%CI: 1.36-3.01). In addition, the higher serum magnesium increased the risk of QTc prolongation, which was significantly only in male population.
conclusionsIn present Chinese rural general population, even with normal range, a decrease in serum potassium and an increase in serum magnesium are important risk factors for QTc prolongation.
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