ArticleBMC evolutionary biology2018
Temperature responses of mutation rate and mutational spectrum in an Escherichia coli strain and the correlation with metabolic rate.
Article in BMC evolutionary biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integrating pH into the metabolic theory of ecology to predict bacterial diversity in soil.Proceedings of the National Academy of Sciences of the United States of America · 2023Pooled it
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- An engineered biofactory for efficient production of diverse recombinant superoxide dismutase isozymes loaded with specific metal ions for biochemical characterization.bioRxiv : the preprint server for biology · 2026Article
- Transition-Transversion Bias at theEcology and evolution · 2026Article
- Evolution of the highest fidelity DNA replication systems.bioRxiv : the preprint server for biology · 2026Article
- Suppressor analysis inFrontiers in microbiology · 2026Article
- The evolution of cancer and ageing: a history of constraint.Nature reviews. Cancer · 2025Review
- Strain-Dependent Thermoadaptation in the Fish PathogenMicroorganisms · 2025Article
- Antimutator and Mutational Spectrum Effects Can Combine to Reduce Evolutionary Potential in Escherichia coli ΔnudJ.Molecular biology and evolution · 2025Article
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- Distinct latitudinal patterns of molecular rates across vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Loss of Heterozygosity associated with ubiquitous environments in yeast.PLoS genetics · 2025Article
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- Deciphering the Foundations of Mitochondrial Mutational Spectra: Replication-Driven and Damage-Induced Signatures Across Chordate Classes.Molecular biology and evolution · 2025Article
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- Variation in the Spectrum of New Mutations among Inbred Strains of Mice.Molecular biology and evolution · 2024Article
- Isolation and characterization of porcine parvovirus in Vietnam.Veterinary world · 2024Article
- Collective peroxide detoxification determines microbial mutation rate plasticity in E. coli.PLoS biology · 2024Article
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6 authors.
Funding
Abstract
backgroundTemperature is a major determinant of spontaneous mutation, but the precise mode, and the underlying mechanisms, of the temperature influences remain less clear. Here we used a mutation accumulation approach combined with whole-genome sequencing to investigate the temperature dependence of spontaneous mutation in an Escherichia coli strain. Experiments were performed under aerobic conditions at 25, 28 and 37 °C, three temperatures that were non-stressful for the bacterium but caused significantly different bacterial growth rates.
resultsMutation rate did not differ between 25 and 28 °C, but was higher at 37 °C. Detailed analyses of the molecular spectrum of mutations were performed; and a particularly interesting finding is that higher temperature led to a bias of mutation to coding, relative to noncoding, DNA. Furthermore, the temperature response of mutation rate was extremely similar to that of metabolic rate, consistent with an idea that metabolic rate predicts mutation rate.
conclusionsTemperature affects mutation rate and the types of mutation supply, both being crucial for the opportunity of natural selection. Our results help understand how temperature drives evolutionary speed of organisms and thus the global patterns of biodiversity. This study also lend support to the metabolic theory of ecology for linking metabolic rate and molecular evolution rate.
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