Evidence map›Paper›PMID 30157316›Full record

ReviewLiver international : official journal of the International Association for the Study of the Liver2019

Hepatitis C elimination among people who inject drugs: Challenges and recommendations for action within a health systems framework.

Emma Day, Margaret Hellard, Carla Treloar, Julie Bruneau, Natasha K Martin, Anne Øvrehus, Olav Dalgard, Andrew Lloyd, John Dillon, Matt Hickman and 10 more

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Liver international : official journal of the International Association for the Study of the Liver, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04610762 (Using the Cepheid GeneXpert HCV VL Fingerstick Test as a Diagnostic Tool for Chronic Hepatitis C Among Drug Users in Brussels), which is not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04610762 completednot on this mapstarted 2020, after this paper: background citation

Using the Cepheid GeneXpert HCV VL Fingerstick Test as a Diagnostic Tool for Chronic Hepatitis C Among Drug Users in Brussels

TypeobservationalSponsorCentre Hospitalier Universitaire Saint PierreRan2020 to 2022Enrolled103ConditionsHepatitis C, ChronicArmsGeneXpert HCV VL Fingerstick test
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 140 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Opportunistic Treatment of Hepatitis C Infection Among Hospitalized People Who Inject Drugs (OPPORTUNI-C): A Stepped Wedge Cluster Randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Trial
  5. Trial
  6. Trial
  7. Low Hepatitis C Reinfection Following Direct-acting Antiviral Therapy Among People Who Inject Drugs on Opioid Agonist Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Implementing a new HCV model of care for people who use drugs.JHEP reports : innovation in hepatology · 2024
    Article
  19. The Urgent Need to Implement Point-of-Care RNA Testing for Hepatitis C Virus to Support Elimination.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 9 countries.

Emma DayAustralasian Society for HIV, Viral Hepatitis, and Sexual Health Medicine, Sydney, New South Wales, Australia.ORCID 0000-0002-4804-4382
Margaret HellardDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.ORCID 0000-0002-5055-3266
Carla TreloarCentre for Social Research in Health, UNSW Sydney, Sydney, New South Wales, Australia.
Julie BruneauCHUM Research Centre (CRCHUM), Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Natasha K MartinDivision of Global Public Health, University of California, San Diego, California.
Anne ØvrehusDepartment of Infectious Diseases, Odense University Hospital, Odense, Denmark.
Olav DalgardDepartment of Infectious Diseases, Institute of Clinical Medicine, Akershus University Hospital, University of Oslo, Oslo, Norway.ORCID 0000-0003-4470-3181
Andrew LloydThe Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.
John DillonDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.ORCID 0000-0002-2164-4476
Matt HickmanPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0001-9864-459X
Jude ByrneAustralian Injecting & Illicit Drug Users League, Canberra, Australian Capital Territory, Australia.
Alain LitwinUniversity of South Carolina School of Medicine Greenville, Greenville, South Carolina.
Mojca MaticicClinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Philip BruggmannArud Centres for Addiction Medicine, Zürich, Switzerland.ORCID 0000-0002-0436-8895
Havard MidgardDepartment of Gastroenterology, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway.
Brianna NortonUniversity of South Carolina School of Medicine Greenville, Greenville, South Carolina.
Stacey TrooskinPhiladelphia FIGHT, Philadelphia, Pennsylvania.
Jeffrey V LazarusBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain.ORCID 0000-0001-9618-2299
Jason GrebelyThe Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-1833-2017
International Network on Hepatitis in Substance Users (INHSU)
UNSW Sydney · AUOslo University Hospital · NOPrisma Health · USAddiction Switzerland · CHAlcohol and Drug Foundation · AUAustralasian Society for HIV, Viral Hepatitis and Sexual Health Medicine · AUBarcelona Institute for Global Health · ESBurnet Institute · AUCentre Hospitalier de l’Université de Montréal · CAOdense University Hospital · DKPhiladelphia Fight · USUniversity of Bristol · GBUniversity of California System · USUniversity of Dundee · GBUniversity of Ljubljana · SI

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
Intensive Models of HCV Care for Injection Drug UsersR01DA034086 · NIDA · CLEMSON UNIVERSITY · PI LITWIN, ALAIN HARRIS · 2012 to 2016
$3.7M
Modeling Structural HIV Determinants in Substance Users and related populationsR01DA037773 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARTIN, NATASHA, STRATHDEE, STEFFANIE A. · 2015 to 2017
$1.4M
Department of Health RP-DG-0610-10055Department of Health RP-PG-0616-20008NIAID NIH HHS P30 AI036214NIDA NIH HHS R01 DA034086NIDA NIH HHS R01 DA037773
6 · The paper itself

Abstract

The burden of hepatitis C infection is considerable among people who inject drugs (PWID), with an estimated prevalence of 39%, representing an estimated 6.1 million people who have recently injected drugs living with hepatitis C infection. As such, PWID are a priority population for enhancing prevention, testing, linkage to care, treatment and follow-up care in order to meet World Health Organization (WHO) hepatitis C elimination goals by 2030. There are many barriers to enhancing hepatitis C prevention and care among PWID including poor global coverage of harm reduction services, restrictive drug policies and criminalization of drug use, poor access to health services, low hepatitis C testing, linkage to care and treatment, restrictions for accessing DAA therapy, and the lack of national strategies and government investment to support WHO elimination goals. On 5 September 2017, the International Network of Hepatitis in Substance Users (INHSU) held a roundtable panel of international experts to discuss remaining challenges and future priorities for action from a health systems perspective. The WHO health systems framework comprises six core components: service delivery, health workforce, health information systems, medical procurement, health systems financing, and leadership and governance. Communication has been proposed as a seventh key element which promotes the central role of affected community engagement. This review paper presents recommended strategies for eliminating hepatitis C as a major public health threat among PWID and outlines future priorities for action within a health systems framework.

Indexed as

Disease EradicationCommunicationGovernment ProgramsHarm ReductionHepatitis CHumansPrevalencePublic HealthSubstance Abuse, IntravenousWorld Health Organizationeliminationhealth systemspeople who inject drugsviral hepatitis C

Identifiers

PMID30157316
PMCPMC6868526
OpenAlexW2889281626

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.