ArticlePloS one2018
Evolutionary history and spatio-temporal dynamics of dengue virus serotypes in an endemic region of Colombia.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Genomic epidemiology of dengue virus 2 and 3 reveals repeated introductions and exportations of several lineages in Colombia.Cell reports · 2026Article
- Unexpected diversification of DENV2 genotype III in Colombia: New Insights and application of the globalized nomenclature.PloS one · 2026Article
- Tracing Dengue's Evolutionary and Phylogenetic Pathways.Current topics in microbiology and immunology · 2026Review
- Integrating machine learning and time-to-event models to explain and predict risk of hospitalization due to dengue in Colombia.Scientific reports · 2025Article
- Genomic epidemiology of dengue virus 2 and 3 reveals repeated introductions and exportations of several lineages in Colombia.medRxiv : the preprint server for health sciences · 2025Article
- Spatiotemporal dispersion of DENV-1 genotype V in Western Colombia.Virus evolution · 2025Article
- Article
- Fatal acute undifferentiated febrile illness among clinically suspected leptospirosis cases in Colombia, 2016-2019.PLoS neglected tropical diseases · 2023Article
- Genotyping of dengue virus from infected tissue samples embedded in paraffin.Virology journal · 2023Article
- Local-scale virome depiction in Medellín, Colombia, supports significant differences between Aedes aegypti and Aedes albopictus.PloS one · 2022Article
- Laboratory Findings in Patients with Probable Dengue Diagnosis from an Endemic Area in Colombia in 2018.Viruses · 2021Article
- Surveillance and Epidemiology of Dengue in Medellín, Colombia from 2009 to 2017.The American journal of tropical medicine and hygiene · 2021Article
- Susceptible host availability modulates climate effects on dengue dynamics.Ecology letters · 2021Article
- Seropositivity and history of hospitalisation for dengue in relation to anthropometric indices among Colombian children and adults.Epidemiology and infection · 2021Article
- Article
- Dengue Infections in Colombia: Epidemiological Trends of a Hyperendemic Country.Tropical medicine and infectious disease · 2020Review
- Heterogeneity of dengue transmission in an endemic area of Colombia.PLoS neglected tropical diseases · 2020Article
- Epidemiology and genetic diversity of circulating dengue viruses in Medellin, Colombia: a fever surveillance study.BMC infectious diseases · 2020Article
- The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia.BMC evolutionary biology · 2020Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue is a prevalent disease in Colombia and all dengue virus serotypes (DENV-1 to -4) co-circulate in the country since 2001. However, the relative impact of gene flow and local diversification on epidemic dynamics is unknown due to heterogeneous sampling and lack of sufficient genetic data. The region of Santander is one of the areas with the highest incidence of dengue in Colombia. To provide a better understanding of the epidemiology of dengue, we inferred DENV population dynamics using samples collected between 1998 and 2015. We used Bayesian phylogenetic analysis and included 143 new envelope gene sequences from Colombia, mainly from the region of Santander, and 235 published sequences from representative countries in the Americas. We documented one single genotype for each serotype but multiple introductions. Whereas the majority of DENV-1, DENV-2, and DENV-4 strains fell into one single lineage, DENV-3 strains fell into two distinct lineages that co-circulated. The inferred times to the most recent common ancestors for the most recent clades of DENV-1, DENV-2, and DENV-4 fell between 1977 and 1987, and for DENV-3 was around 1995. Demographic reconstructions suggested a gradual increase in viral diversity over time. A phylogeographical analysis underscored that Colombia mainly receives viral lineages and a significant diffusion route between Colombia and Venezuela. Our findings contribute to a better understanding of the viral diversity and dengue epidemiology in Colombia.
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