SynthesisPloS one2018
Prevalence and geographical variation of Factor V Leiden in patients with cerebral venous thrombosis: A meta-analysis.
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Cerebral Venous Thrombosis:Current Status and Challenges.Brain and behavior · 2025Review
- Investigation of the relationship between venous thromboembolism and thrombophilic variants.Revista da Associacao Medica Brasileira (1992) · 2025Article
- The genetic risk factors for cerebral venous thrombosis: a case-control study in a Chinese national comprehensive hospital.Thrombosis journal · 2024Article
- An Exploratory Study Using Next-Generation Sequencing to Identify Prothrombotic Variants in Patients with Cerebral Vein Thrombosis.International journal of molecular sciences · 2023Article
- A Comprehensive Review of Risk Factors for Venous Thromboembolism: From Epidemiology to Pathophysiology.International journal of molecular sciences · 2023Review
- Factor V Leiden Mutation Frequency and Geographical Distribution in Turkish Population.Journal of translational internal medicine · 2020Article
- Clinical Impact of Inherited Thrombophilia in Patients With Thrombosis: Evaluating the Real Risk of FVL, PTG20210A, and MTHFR Mutations in the Kurdistan Region of Iraq.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious results regarding the prevalence of Factor V Leiden (FVL) in patients with cerebral venous thrombosis (CVT) varied remarkably. Therefore, we performed a meta-analysis to evaluate the potential association between FVL and CVT.
methodsThe PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science were searched for relevant case-control studies. The data were pooled for analysis of the association between FVL and CVT with a random-effects model. Subgroup and sensitivity analyses were performed to evaluate the robustness of the results. Publication bias was assessed by funnel plot and the Egger's test.
resultsA total of 39 case-control studies including 1807 cases of CVT and 7699 control cases were included. FVL was more common in patients with CVT (195/1822) than in controls(369/7795), [odds ratio(OR) = 2.70, 95% confidence interval(CI) 2.16-3.38, P < 0.00001]. Results of subgroup analyses indicated that the association between FVL and CVT varied according to geographic regions. The associations between FVL and CVT were significant in studies from Germany (OR = 2.42, 95%CI 1.70-3.45, P < 0.00001), Brazil(OR = 2.82, 95%CI 1.24-6.42, P = 0.01), France (OR = 5.44, 95%CI 1.35-21.92, P = 0.02), Iran (OR = 6.61, 95%CI 1.83-23.93, P = 0.004), and Tunisia (OR = 6.54, 95%CI 2.89-14.82, P < 0.00001), but not in those from Italy (OR = 1.49, 95%CI 0.59-3.78, P = 0.40) or the US (OR = 2.37, 95%CI 0.59-9.42, P = 0.22).
conclusionFVL may be more common in patients with CVT. However, the association between FVL and CVT varied depending on the geographic origin of the studies.
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