Evidence map›Paper›PMID 30157179›Full record

Trial reportPloS one2018

1H MR spectroscopy of the motor cortex immediately following transcranial direct current stimulation at 7 Tesla.

Kayla Ryan, Krzysztof Wawrzyn, Joseph S Gati, Blaine A Chronik, Dickson Wong, Neil Duggal, Robert Bartha

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kayla RyanDepartment of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada.ORCID 0000-0001-9572-7410
Krzysztof WawrzynDepartment of Physics and Astronomy, University of Western Ontario, London, ON, Canada.
Joseph S GatiCentre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada.
Blaine A ChronikDepartment of Physics and Astronomy, University of Western Ontario, London, ON, Canada.
Dickson WongDepartment of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-4584-7251
Neil DuggalDepartment of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada.
Robert BarthaDepartment of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada.ORCID 0000-0002-7118-9096
Western University · CA

Funding

Canadian Institute of Health Research 231560
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that may modulate cortical excitability, metabolite concentration, and human behaviour. The supplementary motor area (SMA) has been largely ignored as a potential target for tDCS neurorehabilitation but is an important region in motor compensation after brain injury with strong efferent connections to the primary motor cortex (M1). The objective of this work was to measure tissue metabolite changes in the human motor cortex immediately following tDCS. We hypothesized that bihemispheric tDCS would change levels of metabolites involved in neuromodulation including N-acetylaspartate (NAA), glutamate (Glu), and creatine (tCr). In this single-blind, randomized, cross-over study, fifteen healthy adults aged 21-60 participated in two 7T MRI sessions, to identify changes in metabolite concentrations by magnetic resonance spectroscopy. Immediately after 20 minutes of tDCS, there were no significant changes in metabolite levels or metabolite ratios comparing tDCS to sham. However there was a trend toward increased NAA/tCr concentration (p = 0.08) in M1 under the stimulating cathode. There was a strong, positive correlation between the change in the absolute concentration of NAA and the change in the absolute concentration of tCr (p<0.001) suggesting an effect of tDCS. Both NAA and creatine are important markers of neurometabolism. Our findings provide novel insight into the modulation of neural metabolites in the motor cortex immediately following application of bihemispheric tDCS.

Indexed as

Motor CortexAdultCombined Modality TherapyCortical ExcitabilityCross-Over StudiesEvoked Potentials, MotorFemaleGlutamic AcidHumansMagnetic Resonance SpectroscopyMaleMiddle AgedSingle-Blind MethodTranscranial Direct Current StimulationTranscranial Magnetic StimulationYoung AdultGlutamic Acid

Identifiers

PMID30157179
PMCPMC6114283
OpenAlexW2952356255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.