ArticleMedicine and science in sports and exercise2019
Mediating Effect of Muscle on the Relationship of Physical Activity and Bone.
Article in Medicine and science in sports and exercise, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Cross-sectional and longitudinal associations between the 24-hour movement behaviours, including muscle and bone strengthening activity, with bone and lean mass from childhood to adolescence.BMC public health · 2024Trial
- Associations Between 24-Hour Movement Behaviors and Anthropometric and Body Composition Indicators in Ecuadorian Preschool Children: SUNRISE Pilot Study.Children (Basel, Switzerland) · 2026Article
- Obstructive sleep apnea mediates the association between body mass index and metabolic dysfunction-associated steatotic liver disease in patients with obesity.Hepatology international · 2026Article
- Mediating Role of Muscle Mass in the Relationship Between Physical Activity and Bone Mass in Female University Students in China.PPAR research · 2026Article
- Pathways linking sports participation to bone density and geometry among adolescents: ABCD growth study.Archives of osteoporosis · 2025Article
- Associations Between Youth Sport Participation and Bone, Muscle, and Fat in Adulthood: Iowa Bone Development Study.International journal of environmental research and public health · 2025Article
- Determinants of bone parameters in young paediatric cancer survivors: the iBoneFIT project.Pediatric research · 2023Article
- Review
- A comprehensive normative reference database of muscle morphology in typically developing children aged 3-18 years-a cross-sectional ultrasound study.Journal of anatomy · 2023Article
- Interrelationship between muscle fitness in childhood and bone mineral density in adulthood: mediation analysis of muscle fitness in adulthood.BMC public health · 2023Article
- The Influence of Accelerometer Epoch Length on Associations of Physical Activity Intensity and Volume with Bone Outcomes.Journal of sports science & medicine · 2023Article
- Physical activity volume and intensity distribution in relation to bone, lean and fat mass in children.Scandinavian journal of medicine & science in sports · 2023Article
- Exercise-induced modulation of myokine irisin in bone and cartilage tissue-Positive effects on osteoarthritis: A narrative review.Frontiers in aging neuroscience · 2022Review
- Relationship between body composition and bone mass in normal-weight and overweight adolescents.PeerJ · 2022Article
- Effects of rearing systems on the eggshell quality, bone parameters and expression of genes related to bone remodeling in aged laying hens.Frontiers in physiology · 2022Article
- Influential role of lean soft tissue in the association between training volume and bone mineral density among male adolescent practitioners of impact-loading sports: ABCD Growth study.BMC pediatrics · 2020Article
- Relationship between smoking status and muscle strength in the United States older adults.Epidemiology and health · 2020Article
- Association of objectively measured physical activity and sedentary behavior with bone stiffness in peripubertal children.Journal of bone and mineral metabolism · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThis study analyzed prospective associations between distinct trajectories of objectively measured physical activity (PA) and late adolescent bone parameters and explored the mediating effects of lean soft tissue, a surrogate of muscle mass to associations.
methodsPhysical activity was measured by accelerometry starting at age 5 yr and continuing at 8, 11, 13, 15, and 17 yr in approximately 524 participants from the Iowa Bone Development Study. Sex-specific group-based trajectory modeling was used to construct developmental trajectories of moderate- and vigorous-intensity PA (MVPA) from childhood to late adolescence. At age 17 yr, proximal femur bone mineral density (aBMD) was assessed by dual X-ray energy absorptiometry, and its distribution was calculated by aBMD ratios. Specific geometric measures of the proximal femur were assessed using hip structural analysis.
resultsA significant portion of the total effect of MVPA from age 5 to 17 yr on bone parameters at age 17 yr was explained by an increase in leg lean soft tissue in both sexes. For males and females, indirect effects were observed on the total and all regional proximal femur aBMD, and on the ratio between the inferomedial and superolateral neck aBMD. The effect on the ratio between the trochanter and the total proximal femur was specific to females, whereas the effect on the hip axis length was specific to males. Direct effects of MVPA on aBMD were identified only in males.
conclusionsUsing robust mediation analysis, this is the first study addressing the indirect effect (through muscle) of PA across childhood and adolescence on proximal femur bone parameters. To improve bone health at the proximal femur, the results suggest PA interventions during growth that increase muscle mass, particularly in females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.