Evidence map›Paper›PMID 30156264›Full record

ArticleFEBS letters2018

Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26.

Louise J Walport, Richard J Hopkinson, Rasheduzzaman Chowdhury, Yijia Zhang, Joanna Bonnici, Rachel Schiller, Akane Kawamura, Christopher J Schofield

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Structure-guided optimisation ofChemical science · 2023
    Article
  5. Article
  6. Histone variant-specific post-translational modifications.Seminars in cell & developmental biology · 2023
    Review
  7. Article
  8. Mechanistic insights into KDM4A driven genomic instability.Biochemical Society transactions · 2021
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Louise J WalportDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, UK.ORCID 0000-0002-3795-8365
Richard J HopkinsonDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, UK.ORCID 0000-0001-7610-8163
Rasheduzzaman ChowdhuryDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, UK.
Yijia ZhangDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, UK.
Joanna BonniciDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, UK.
Rachel SchillerDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, UK.
Akane KawamuraDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, UK.ORCID 0000-0003-1169-5082
Christopher J SchofieldDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, UK.

Funding

Biotechnology and Biological Sciences Research CouncilCancer Research UK 18245Cancer Research UK C8717/A18245Wellcome TrustWellcome Trust 091857/7/10/7
6 · The paper itself

Abstract

N-Methylation of lysyl residues is widely observed on histone proteins. Using isolated enzymes, we report mechanistic and structural studies on histone lysine demethylase (KDM)-catalysed demethylation of N

Indexed as

DemethylationAmino Acid SequenceBiocatalysisCrystallography, X-RayHistonesHumansJumonji Domain-Containing Histone DemethylasesKineticsLysineProtein BindingProtein ConformationSequence Homology, Amino AcidHistonesJumonji Domain-Containing Histone DemethylasesKDM4A protein, humanLysine2-oxoglutarate oxygenasesdemethylasesepigeneticshistonesJmjC demethylaseslysine N-methylation

Identifiers

PMID30156264
PMCPMC6220849

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.