ReviewThe journal of obstetrics and gynaecology research2019
Fibrinogen for the management of critical obstetric hemorrhage.
Review in The journal of obstetrics and gynaecology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 46 citations in OpenAlex.
- Maternal Severity and Diagnostic Validity of the Revised Japanese Criteria for Obstetric Disseminated Intravascular Coagulation: A Retrospective Observational Study.The journal of obstetrics and gynaecology research · 2026Observational
- "No End Point Detected": A Unique Coagulation Profile Unmasking Dysfibrinogenemia.Case reports in hematology · 2025Article
- [Obstetrical disseminated intravascular coagulation: a case report and literature review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Review
- Changes in use and outcomes after fibrinogen concentrate insurance coverage for critical obstetrical hemorrhage: a nationwide questionnaire survey in Japan.Scientific reports · 2024Article
- Effectiveness of call system implementation for postpartum hemorrhage in a tertiary emergency medical center: a retrospective cohort study.BMC pregnancy and childbirth · 2023Article
- Fibrinogen for the prediction of severe maternal complications in placental abruption with fetal death after 24 weeks of gestation.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023Article
- Delivery decision in pregnant women rescued by ECMO for severe ARDS: a retrospective multicenter cohort study.Critical care (London, England) · 2022Article
- Diagnostic and Therapeutic Potential for HNP-1, HBD-1 and HBD-4 in Pregnant Women with COVID-19.International journal of molecular sciences · 2022Article
- Effect of hypofibrinogenemia on obstetrical disseminated intravascular coagulation in Japan in 2018: a multicenter retrospective cohort study.International journal of hematology · 2021Article
- Blood component therapy in patients having massive obstetric hemorrhage in a tertiary care center in Puducherry.Asian journal of transfusion scienceArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIn cases of critical obstetric hemorrhage leading to extreme hypofibrinogenemia, fibrinogen is the marker that indicates the critical severity, and early fibrinogen supplementation centering on hemostatic resuscitation is a vital treatment to stabilize a catastrophic condition. In this review, we investigated the effect of fibrinogen level on hemostasis and what we can do to treat hypofibrinogenemia efficiently and improve patients' outcome.
methodsWe reviewed numerous articles related to hypofibrinogenemia in critical obstetric hemorrhage. Especially, we performed a systematic review on target value of fibrinogen for hemostasis and effectiveness of fibrinogen concentrate. We also reviewed the articles about the methods for early normalization of fibrinogen level such as tranexamic acid, massive transfusion protocol, and point-of-care testing.
resultsThe target value of fibrinogen calculated by needs for massive transfusion was 200 mg/dL or 10 mm of A5
conclusionThe patient group for which fibrinogen concentrate works most effectively is cases with severe hypofibrinogenemia. Further research is required in the light of evidence. The essence of the transfusion algorithm in critical obstetric hemorrhage is to approach the target value for obtaining hemostasis, ensure an accurate and prompt grasp of the severity using point-of-care testing, introduce a massive transfusion protocol and use tranexamic acid.
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