ArticleChemistry (Weinheim an der Bergstrasse, Germany)2018
Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- The effect of charge and albumin on cellular uptake of supramolecular polymer nanostructures.Journal of materials chemistry. B · 2024Article
- Complexation Preferences of Dynamic Constitutional Frameworks as Adaptive Gene Vectors.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Hierarchical self-assembly of aromatic peptide conjugates into supramolecular polymers: it takes two to tango.Chemical science · 2022Review
- Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform.Angewandte Chemie (International ed. in English) · 2021Article
- Supramolecular Nanoscaffolds within Cytomimetic Protocells as Signal Localization Hubs.Journal of the American Chemical Society · 2020Article
- Multivalent Ultrasensitive Interfacing of Supramolecular 1D Nanoplatforms.Journal of the American Chemical Society · 2019Article
- DNA-Functionalized Supramolecular Polymers: Dynamic Multicomponent Assemblies with Emergent Properties.Bioconjugate chemistry · 2019Review
- Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The cellular uptake of self-assembled biological and synthetic matter results from their multicomponent properties. However, the interplay of the building block composition of self-assembled materials and uptake mechanisms urgently requires addressing. It is shown here that supramolecular polymers that self-assemble in aqueous media, are a modular and controllable platform to modulate cellular delivery by the introduction of small ligands or cationic moieties, with concomitantly different cellular uptake kinetics and valence dependence. A library of supramolecular copolymers revealed stringent mutually exclusive uptake behavior in which either of the uptake pathways dominated, with sharp compositional transition. Supramolecular biomaterial engineering thus provides for adaptive platforms with great potential for efficient tuning of multivalent and multicomponent systems interfacing with biological matter.
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Registered trials
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