Evidence map›Paper›PMID 30155917›Full record

ArticleAllergy2019

Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization.

Zhongshan Gao, Wan-Yi Fu, Yuemei Sun, Biyuan Gao, Hui-Ying Wang, Meiling Liu, Fang-Mei Luo, Xiang Zhou, Jing Jin, Lan Zhao and 12 more

Open access · hybridAbstract read
In one paragraph

Article in Allergy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. [Epidemiological investigation and risk factors analysis of allergic rhinitis induced by Artemisia pollen in northern China].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Article
  5. Evolution of IgE sensitization profiles toThe World Allergy Organization journal · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Pollen-Food Allergy Syndrome in China: Current Knowledge and Future Research Needs.International archives of allergy and immunology · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 11 institutions in 3 countries.

Zhongshan GaoAllergy Research Center, Zhejiang University, Hangzhou, China.ORCID 0000-0001-6944-9955
Wan-Yi FuCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Yuemei SunDepartment of Allergy, Yu Huang Ding Hospital, Yantai, China.
Biyuan GaoHangzhou Aileji Biotech Ltd, Hangzhou, China.
Hui-Ying WangDepartment of Allergy, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Meiling LiuDepartment of Allergy, The Third People's Hospital of Datong, Shanxi, China.
Fang-Mei LuoDepartment of Otorhinolaryngology, Qujing Chinese Traditional Medicine Hospital, Yunnan, China.
Xiang ZhouCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Jing JinCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Lan ZhaoCollege of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Shandong WuAllergy Research Center, Zhejiang University, Hangzhou, China.
Yi LiuAllergy Research Center, Zhejiang University, Hangzhou, China.
Lingying WuDepartment of Allergy, The Third People's Hospital of Datong, Shanxi, China.
Xuefeng WangDepartment of Allergy, The Third People's Hospital of Datong, Shanxi, China.
Ning-Bo TangDepartment of Allergy, Yu Huang Ding Hospital, Yantai, China.
Bao-Hua GuoDepartment of Otorhinolaryngology, Qujing Chinese Traditional Medicine Hospital, Yunnan, China.
Yan FengDepartment of Otorhinolaryngology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan, China.
Jian Ying ZhouDepartment of Respiratory Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Gabriele GadermaierDepartment of Biosciences, University of Salzburg, Salzburg, Austria.ORCID 0000-0002-4886-417X
Fatima FerreiraDepartment of Biosciences, University of Salzburg, Salzburg, Austria.ORCID 0000-0003-0989-2335
Serge A VersteegDepartment of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Ronald van ReeDepartment of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Zhejiang A & F University · CNShanxi Datong University · CNAmsterdam University Medical Centers · NLUniversity of Salzburg · ATYuhuangding Hospital · CNYunnan Provincial Hospital of Traditional Chinese Medicine · CNZhejiang University · CNFirst Affiliated Hospital Zhejiang University · CNHangzhou DAC Biotech (China) · CNSecond Affiliated Hospital of Zhejiang University · CNShanxi Medical University · CN

Funding

Hangzhou Aileji Biotech Ltd, China 2016-R1National Natural Science Foundation of China 31772271
6 · The paper itself

Abstract

backgroundArtemisia pollen allergy is a major cause of asthma in Northern China. Possible associations between IgE responses to Artemisia allergen components and clinical phenotypes have not yet been evaluated. This study was to establish sensitization patterns of four Artemisia allergens and possible associations with demographic characteristics and clinical phenotypes in three areas of China.

methodsTwo hundred and forty patients allergic to Artemisia pollen were examined, 178 from Shanxi and 30 from Shandong Provinces in Northern China, and 32 from Yunnan Province in Southwestern China. Allergic asthma, rhinitis, conjunctivitis, and eczema symptoms were diagnosed. All patients' sera were tested by ImmunoCAP with mugwort pollen extract and the natural components nArt v 1, nArt ar 2, nArt v 3, and nArt an 7.

resultsThe frequency of sensitization and the IgE levels of the four components in Artemisia allergic patients from Southwestern China were significantly lower than in those from the North. Art v 1 and Art an 7 were the most frequently recognized allergens (84% and 87%, respectively), followed by Art v 3 (66%) and Art ar 2 (48%). Patients from Northern China were more likely to have allergic asthma (50%) than patients from Southwestern China (3%), and being sensitized to more than two allergens increased the risk of allergic asthma, in which co-sensitization to three major allergens Art v 1, Art v 3, and Art an 7 is prominent.

conclusionsComponent-resolved diagnosis of Chinese Artemisia pollen-allergic patients helps assess the potential risk of mugwort-associated allergic asthma.

Indexed as

AdolescentAdultAntigens, PlantArtemisiaChildChild, PreschoolCross ReactionsFemaleHumansImmunizationImmunoglobulin EMaleMiddle AgedPhenotypePollenRhinitis, Allergic, SeasonalAntigens, PlantImmunoglobulin EArtemisia pollen allergyasthmacomponent-resolved diagnosis

Identifiers

PMID30155917
PMCPMC6587742
OpenAlexW2889439914

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.