Evidence map›Paper›PMID 30155805›Full record

ArticleNeurochemical research2018

Effects of NMDAR Antagonist on the Regulation of P-MARCKS Protein to Aβ

Yudong Liu, Peng Zhang, Yabing Zheng, Chunlin Yang, Tong Du, Mengru Ge, Xiaotian Chang, Ruisheng Duan, Guozhao Ma

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yudong LiuDepartment of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, People's Republic of China.
Peng ZhangDepartment of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, People's Republic of China.
Yabing ZhengCentral Laboratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, People's Republic of China.
Chunlin YangDepartment of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, People's Republic of China.
Tong DuDepartment of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, People's Republic of China.
Mengru GeDepartment of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, People's Republic of China.
Xiaotian ChangCentral Laboratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, People's Republic of China.
Ruisheng DuanDepartment of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, People's Republic of China.
Guozhao MaDepartment of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, People's Republic of China. maguozhao@163.com.
Shandong University · CNShandong Provincial QianFoShan Hospital · CN

Funding

National Natural Science Foundation of China (CN) 30600202National Natural Science Foundation of China (CN) 30710303072National Natural Science Foundation of China (CN) 30870874
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a well-known neurodegenerative disease. Deposition of β-amyloid protein (Aβ) oligomers plays a crucial role in the disease progression. Previous studies showed that toxicity induced by Aβ oligomers in cultured neurons and adult rat brain was partially mediated by activation of glutamatergic N-methyl-D-aspartate receptors (NMDAR). Additionally, memantine, a noncompetitive NMDAR antagonist, can significantly improve cognitive functions in some AD patients. However, little is currently known about the potential role of NMDAR antagonist on the regulation of P-MARCKS protein to Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsApoptosisCells, CulturedCell SurvivalFemaleMaleMyristoylated Alanine-Rich C Kinase SubstrateNeuronsNeuroprotective AgentsNeurotoxicity SyndromesPeptide FragmentsRatsReceptors, N-Methyl-D-AspartateAmyloid beta-PeptidesMyristoylated Alanine-Rich C Kinase SubstrateNeuroprotective AgentsPeptide FragmentsReceptors, N-Methyl-D-AspartateAlzheimer’s diseaseAβ1−42 oligomersCell apoptosisP-MARCKSSynaptic plasticity

Identifiers

PMID30155805
OpenAlexW2889505581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.