ArticleBrain imaging and behavior2019
Smaller subcortical volume in Parkinson patients with rapid eye movement sleep behavior disorder.
Article in Brain imaging and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gray matter structural and functional brain abnormalities in Parkinson's disease: a meta-analysis of VBM and ALFF data.Journal of neurology · 2025Pooled it
- Reduced volume of the mediodorsal and anteroventral thalamus is associated with anxiety in Parkinson's disease: A cross-sectional 7-tesla MRI study.Journal of Parkinson's disease · 2025Article
- Cerebellum and basal ganglia connectivity in isolated REM sleep behaviour disorder and Parkinson's disease: an exploratory study.Brain imaging and behavior · 2024Article
- MRI findings in movement disorders and associated sleep disturbances.American journal of nuclear medicine and molecular imaging · 2023Review
- Morphological changes in Parkinson's disease based on magnetic resonance imaging: A mini-review of subcortical structures segmentation and shape analysis.World journal of psychiatry · 2022Review
- Putamen Atrophy Is a Possible Clinical Evaluation Index for Parkinson's Disease Using Human Brain Magnetic Resonance Imaging.Journal of imaging · 2022Article
- Imaging the Limbic System in Parkinson's Disease-A Review of Limbic Pathology and Clinical Symptoms.Brain sciences · 2022Review
- Assessing the joint effects of brain aging and gut microbiota on the risks of psychiatric disorders.Brain imaging and behavior · 2022Article
- Brain atrophy pattern in de novo Parkinson's disease with probable RBD associated with cognitive impairment.NPJ Parkinson's disease · 2022Article
- Diffusion Tensor Imaging Reveals Deep Brain Structure Changes in Early Parkinson's Disease Patients with Various Sleep Disorders.Brain sciences · 2022Article
- Sex differences in brain atrophy and cognitive impairment in Parkinson's disease patients with and without probable rapid eye movement sleep behavior disorder.Journal of neurology · 2022Article
- Disrupted Brain Structural Network Connection inFrontiers in human neuroscience · 2022Article
- Disrupted functional connectivity in PD with probable RBD and its cognitive correlates.Scientific reports · 2021Article
- Morphological analysis of subcortical structures for assessment of cognitive dysfunction in Parkinson's disease using multi-atlas based segmentation.Cognitive neurodynamics · 2021Article
- The Correlation Between Parkinson's Disease and Rapid Eye Movement Sleep Behavior Disorder: A Systematic Review.Cureus · 2021Review
- Thalamic atrophy in patients with pure hereditary spastic paraplegia type 4.Journal of neurology · 2021Article
- Abnormal Gray Matter Volume and Functional Connectivity in Parkinson's Disease with Rapid Eye Movement Sleep Behavior Disorder.Parkinson's disease · 2021Article
- Neuroimaging Advances in Parkinson's Disease and Atypical Parkinsonian Syndromes.Frontiers in neurology · 2020Review
- Altered Brain Functional Network in Parkinson Disease With Rapid Eye Movement Sleep Behavior Disorder.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Parkinson disease (PD) patients with rapid eye movement (REM) sleep behavior disorder (RBD) have worse motor symptoms and non-motor symptoms than patients without RBD. The aim of this study was to examine underlying differences in brain structure from a network perspective. Baseline data were obtained from Parkinson's Progression Markers Initiative (PPMI) participants. We divided PD patients and healthy controls (HC) into RBD positive and RBD negative using a cutoff score of ≥5 on the RBD screening questionnaire. HC with probable RBD were excluded. We first carried out a region-of-interest analysis of structural MRIs using voxel-based morphometry to study volumetric differences for the putamen, thalamus and hippocampus in a cross-sectional design. Additionally, an exploratory whole-brain analysis was performed. To study group differences from a network perspective, we then performed a 'seed-based' analysis of structural covariance, using the bilateral dorsal-caudal putamen, mediodorsal thalamus and anterior hippocampus as seed regions. The volume of the right putamen was smaller in PD patients with RBD. RBD symptom severity correlated negatively with volume of the right putamen, left hippocampus and left thalamus. We did not find any differences in structural covariance between PD patients with and without RBD. Presence of RBD and severity of RBD symptoms in PD are associated with smaller volumes of the putamen, thalamus and hippocampus.
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Registered trials
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