Evidence map›Paper›PMID 30155748›Full record

ArticlePsychopharmacology2019

Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function.

Sofia Cussotto, Conall R Strain, Fiona Fouhy, Ronan G Strain, Veronica L Peterson, Gerard Clarke, Catherine Stanton, Timothy G Dinan, John F Cryan

Abstract read
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In one paragraph

Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 3 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 3 syntheses or guidelines pooled it, 258 citations in OpenAlex.

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81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sofia CussottoAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Conall R StrainAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Fiona FouhyAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Ronan G StrainAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Veronica L PetersonAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Gerard ClarkeAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Catherine StantonAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Timothy G DinanAPC Microbiome Ireland, University College Cork, Cork, Ireland. t.dinan@ucc.ie.
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland. j.cryan@ucc.ie.
University College Cork · IEAPC Microbiome Institute · IETeagasc - The Irish Agriculture and Food Development Authority · IE

Funding

Science Foundation Ireland 12/RC/2273
6 · The paper itself

Abstract

rationaleGrowing evidence supports a role for the microbiota in regulating gut-brain interactions and, thus, psychiatric disorders. Despite substantial scientific efforts to delineate the mechanism of action of psychotropic medications at a central nervous system (CNS) level, there remains a critical lack of understanding on how these drugs might affect the microbiota and gut physiology.

objectivesWe investigated the antimicrobial activity of psychotropics against two bacterial strain residents in the human gut, Lactobacillus rhamnosus and Escherichia coli. In addition, we examined the impact of chronic treatment with these drugs on microbiota and intestinal parameters in the rat.

resultsIn vitro fluoxetine and escitalopram showed differential antimicrobial effects. Lithium, valproate and aripiprazole administration significantly increased microbial species richness and diversity, while the other treatments were not significantly different from controls. At the genus level, several species belonging to Clostridium, Peptoclostridium, Intestinibacter and Christenellaceae were increased following treatment with lithium, valproate and aripiprazole when compared to the control group. Animals treated with escitalopram, venlafaxine, fluoxetine and aripiprazole exhibited an increased permeability in the ileum.

conclusionsThese data show that psychotropic medications differentially influence the composition of gut microbiota in vivo and that fluoxetine and escitalopram have specific antimicrobial activity in vitro. Interestingly, drugs that significantly altered gut microbial composition did not increase intestinal permeability, suggesting that the two factors are not causally linked. Overall, unravelling the impact of psychotropics on gastrointestinal and microbiota measures offers the potential to provide critical insight into the mechanism of action and side effects of these medications.

Indexed as

AnimalsAnti-Bacterial AgentsDose-Response Relationship, DrugEscherichia coliGastrointestinal MicrobiomeGastrointestinal TractHumansLacticaseibacillus rhamnosusMalePsychotropic DrugsRatsRats, Sprague-DawleyAnti-Bacterial AgentsPsychotropic DrugsAntimicrobialDiversityGut microbiotaIntestinal permeabilityPsychotropicsRichnessShort-chain fatty acids

Identifiers

PMID30155748
OpenAlexW2889513832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.