Evidence map›Paper›PMID 30155672›Full record

ArticleJournal of thrombosis and thrombolysis2018

Comparison of rivaroxaban concentrations between Asians and Caucasians and their correlation with PT/INR.

Hobart Owen Ng Tsai, Janice Jia Ni Goh, Jernice Wan Xin Aw, Yingying Lin, Alan Yean Yip Fong, Lee Len Tiong, Doreen Su-Yin Tan

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hobart Owen Ng TsaiDepartment of Pharmacy, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore, 768828, Singapore. ngtsai.hobart.owen@ktph.com.sg.ORCID http://orcid.org/0000-0001-9760-7930
Janice Jia Ni GohDepartment of Pharmacy, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore, 768828, Singapore.
Jernice Wan Xin AwDepartment of Pharmacy, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore, 768828, Singapore.
Yingying LinDepartment of Pharmacy, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore, 768828, Singapore.
Alan Yean Yip FongConsultant Cardiologist, Sarawak Heart Centre, Kuching - Samarahan Expressway, 94300, Kota Samarahan, Sarawak, Malaysia.
Lee Len TiongClinical Research Centre, Sarawak General Hospital, Jalan Hospital, 93586, Kuching, Sarawak, Malaysia.
Doreen Su-Yin TanDepartment of Pharmacy, Khoo Teck Puat Hospital, 90 Yishun Central, Singapore, 768828, Singapore.

Funding

National Medical Research Council (NRMC) Centre Grant Pitch-For-Fund PFF15001
6 · The paper itself

Abstract

The objectives of this study are to compare steady-state trough (Cmin,ss) and peak (Cmax,ss) concentrations of rivaroxaban between Asians and Caucasians and to evaluate the relationship between rivaroxaban concentrations and prothrombin time/international normalized ratio (PT/INR). Recruited patients were advised on the time to take rivaroxaban. Cmin,ss and PT/INR were taken when patients arrived. Cmax,ss and PT/INR were drawn between 2 and 4 h later after the patient took rivaroxaban with food. Thirty patients were included in the analyses: 57% (n = 17) males and 43% (n = 13) females, 77% (n = 23) on 20 mg and 23% (n = 7) on 15 mg. Median PT

Indexed as

Asian PeopleBlood Coagulation TestsWhite PeopleAdultBody Mass IndexFemaleHumansInternational Normalized RatioMaleProthrombin TimeRivaroxabanRivaroxabanAsianINRPlasma concentrationPTRivaroxaban

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.