ReviewCurrent psychiatry reports2018
Neuroimaging Predictors and Mechanisms of Treatment Response in Social Anxiety Disorder: an Overview of the Amygdala.
Review in Current psychiatry reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- From gut to brain: unveiling probiotic effects through a neuroimaging perspective-A systematic review of randomized controlled trials.Frontiers in nutrition · 2024Pooled it
- Gray matter abnormalities in patients with major depressive disorder and social anxiety disorder: a voxel-based meta-analysis.Brain imaging and behavior · 2023Pooled it
- Meta-analytic evidence that mindfulness training alters resting state default mode network connectivity.Scientific reports · 2022Pooled it
- Trial
- Emotion-based brain mechanisms and predictors for SSRI and CBT treatment of anxiety and depression: a randomized trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Connectivity between the central executive and salience networks normalizes with exposure-focused CBT in pediatric anxiety.medRxiv : the preprint server for health sciences · 2026Article
- Amygdala-insula response to neutral stimuli and the prospective prediction of anxiety sensitivity.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- Effects of Intermittent Fasting on Anxiety and the Functional Connectivity of the Amygdala in Healthy Adults.Alpha psychiatry · 2025Article
- Group-to-individual generalizability and individual-level inferences in cognitive neuroscience.Neuroscience and biobehavioral reviews · 2025Review
- Adolescent social anxiety is associated with diminished discrimination of anticipated threat and safety in the bed nucleus of the stria terminalis.Journal of psychopathology and clinical science · 2025Article
- Association between subcortical nuclei volume changes and cognition in preschool-aged children with tetralogy of Fallot after corrective surgery: a cross-sectional study.Italian journal of pediatrics · 2024Article
- Resting-state amygdala subregion and precuneus connectivity provide evidence for a dimensional approach to studying social anxiety disorder.Translational psychiatry · 2024Article
- Neural and Cognitive Predictors of Stimulant Treatment Efficacy in Medication-Naïve ADHD Adults: A Pilot Diffusion Tensor Imaging Study.Journal of attention disorders · 2024Article
- An exploration of neural predictors of treatment compliance in cognitive-behavioral group therapy for hoarding disorder.Journal of affective disorders · 2024Article
- The regulative role and mechanism of BNST in anxiety disorder.Frontiers in psychiatry · 2024Review
- Informing the treatment of social anxiety disorder with computational and neuroimaging data.Psychoradiology · 2024Article
- Functional connectivity of amygdala subnuclei in PTSD: a narrative review.Molecular psychiatry · 2023Review
- Candidate biomarkers in psychiatric disorders: state of the field.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Individual cognitive therapy reduces frontal-thalamic resting-state functional connectivity in social anxiety disorder.Frontiers in psychiatry · 2023Article
- Cortical-subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala.Science advances · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewAberrant amygdala activity is implicated in the neurobiology of social anxiety disorder (SAD) and is, therefore, a treatment target. However, the extent to which amygdala predicts clinical improvement or is impacted by treatment has not been critically examined. This review highlights recent neuroimaging findings from clinical trials and research that test links between amygdala and mechanisms of action. RECENT
findingsNeuropredictor studies largely comprised psychotherapy where improvement was foretold by amygdala activity and regions beyond amygdala such as frontal structures (e.g., anterior cingulate cortex, medial prefrontal cortex) and areas involved in visual processes (e.g., occipital regions, superior temporal gyrus). Pre-treatment functional connectivity between amygdala and frontal areas was also shown to predict improvement signifying circuits that support emotion processing and regulation interact with treatment. Pre-to-post studies revealed decreases in amygdala response and altered functional connectivity in amygdala pathways regardless of treatment modality. In analogue studies of fear exposure, greater reduction in anxiety was predicted by less amygdala response to a speech challenge and amygdala activity decreased following exposures. Yet, studies have also failed to detect amygdala effects reporting instead treatment-related changes in regions and functional systems that support sensory, emotion, and regulation processes. An array of regions in the corticolimbic subcircuits and extrastriate cortex appear to be viable sites of action. The amygdala and amygdala pathways predict treatment outcome and are altered following treatment. However, further study is needed to establish the role of the amygdala and other candidate regions and brain circuits as sites of action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.