ArticleAmerican journal of clinical dermatology2018
A Comprehensive Conceptual Model of the Experience of Chronic Itch in Adults.
Article in American journal of clinical dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of autoimmune blistering disease, and specifically, pemphigus vulgaris, with cardiovascular disease and its risk factors: a systematic review and meta-analysis.Archives of dermatological research · 2023Pooled it
- Patients' Experiences of Atopic Dermatitis and Nemolizumab Treatment: An In-Trial Interview Study Embedded in a Phase 3 Clinical Trial (ARCADIA).The patient · 2025Trial
- Psychometric validation and responder definition of the sleep disturbance numerical rating scale in moderate-to-severe atopic dermatitis.The British journal of dermatology · 2022Trial
- Impact of baricitinib in combination with topical steroids on atopic dermatitis symptoms, quality of life and functioning in adult patients with moderate-to-severe atopic dermatitis from the BREEZE-AD7 Phase 3 randomized trial.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Trial
- Development of a Conceptual Disease Model of Atopic Dermatitis Using Data from the Phase 3 ARCADIA 1 Trial.Dermatology and therapy · 2026Article
- Concept elicitation and development of a patient-centric conceptual disease model in chronic pruritus of unknown origin.Journal of patient-reported outcomes · 2026Article
- Catastrophizing in Chronic Itch: Associations with Demographic, Clinical and Psychological Factors.Acta dermato-venereologica · 2026Article
- A Conceptual Disease Model of Symptoms and Impacts in Adults with Prurigo Nodularis: A Qualitative and Literature-Informed Study.Dermatology and therapy · 2026Article
- Prurigo Nodularis PaTient-Reported BurdEn of SicKness (PN TREK): A Cross-Sectional Survey of Patient-Reported Burden of Disease in Patients with PN from the US.Advances in therapy · 2025Article
- Capturing patient-reported sleep disturbance in atopic dermatitis clinical trials.Journal of patient-reported outcomes · 2024Review
- DESCRIBE-AD: A novel classification framework for atopic dermatitis.Journal of the American Academy of Dermatology · 2022Review
- The translational revolution of itch.Neuron · 2022Review
- Article
- Living with a chronic disease: insights from patients with a low socioeconomic status.BMC family practice · 2021Article
- Impact of Itch on Sleep Disturbance in Patients with Prurigo Nodularis.Acta dermato-venereologica · 2021Article
- Content validity of a sleep numerical rating scale and a sleep diary in adults and adolescents with moderate-to-severe atopic dermatitis.Journal of patient-reported outcomes · 2020Article
- Development, Validation, and Interpretation of the PROMIS Itch Questionnaire: A Patient-Reported Outcome Measure for the Quality of Life Impact of Itch.The Journal of investigative dermatology · 2020Article
- Measurement properties of three assessments of burden used in atopic dermatitis in adults.The British journal of dermatology · 2019Article
- Iatrogenic Burden of Atopic Dermatitis.Dermatitis : contact, atopic, occupational, drugReview
- Mental Health Symptoms and Functional Impairment in Children With Atopic Dermatitis.Dermatitis : contact, atopic, occupational, drugArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundItch is common and often debilitating. Itch is best assessed by self-report, often using patient-reported outcome measures (PROMs). Current PROMs for itch are limited and may not capture its full impact on quality of life (QOL).
objectiveWe sought to develop a comprehensive conceptual model of itch to improve the understanding of itch for clinicians and to serve as a framework for development of efficient and valid PROMs of itch.
methodsUsing mixed methods, including systematic review (n = 491 articles), semi-structured interviews (n = 33 adults with chronic itch with multiple etiologies), and grounded theory using a constant comparative approach, we developed a conceptual model of itch.
resultsWe found the Wilson and Cleary model to be a reasonable framework for organizing our findings. It includes five primary components: biological and physiological variables, symptom status, functional status, general health perceptions, and QOL. We propose a causal relationship beginning with the biological and physiological driving factors, with direct and indirect impacts of itch and its sequelae, including pain and sleep disturbance. These can impair function, lead to task avoidance, stigma, social life and relationship problems, emotional disturbances, and treatment burden. Together, these sequelae alter one's perceptions of health, QOL, and treatment response.
conclusionsOur conceptual model demonstrates the profound patient-burden of itch and identifies unmet needs in the evaluation and management of itch.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.