ArticleFrontiers in bioengineering and biotechnology2018
Article in Frontiers in bioengineering and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- The influence of different crosslinking agents onto the physical properties, integration behavior and immune response of collagen-based barrier membranes.Frontiers in bioengineering and biotechnology · 2024Article
- Endowing improved osteogenic activities with collagen membrane by incorporating biocompatible iron oxide nanoparticles.Frontiers in bioengineering and biotechnology · 2023Article
- Effects and metabolism of fish collagen sponge in repairing acute wounds of rat skin.Frontiers in bioengineering and biotechnology · 2023Article
- Biofunctionalization of Xenogeneic Collagen Membranes with Autologous Platelet Concentrate-Influence on Rehydration Protocol and Angiogenesis.Biomedicines · 2022Article
- The feasibility of injectable PRF (I-PRF) for bone tissue engineering and its application in oral and maxillofacial reconstruction: From bench to chairside.Biomaterials advances · 2022Review
- Development and characterization of poultry collagen-based hybrid hydrogels for bone regeneration.Acta cirurgica brasileira · 2022Article
- Further structural characterization of ovine forestomach matrix and multi-layered extracellular matrix composites for soft tissue repair.Journal of biomaterials applications · 2022Article
- From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release.International journal of molecular sciences · 2021Review
- Multinucleated Giant Cells Induced by a Silk Fibroin Construct Express Proinflammatory Agents: An Immunohistological Study.Materials (Basel, Switzerland) · 2021Article
- Pharyngeal spreading of peri-implant infections under antiresorptive/antiangiogenic therapy.International journal of implant dentistry · 2021Article
- Article
- Multinucleated giant cells within the in vivo implantation bed of a collagen-based biomaterial determine its degradation pattern.Clinical oral investigations · 2021Article
- Biofunctionalization of porcine-derived collagen matrices with platelet rich fibrin: influence on angiogenesis in vitro and in vivo.Clinical oral investigations · 2020Article
- Modification of collagen-based sponges can induce an upshift of the early inflammatory response and a chronic inflammatory reaction led by M1 macrophages: an in vivo study.Clinical oral investigations · 2020Article
- In Vivo Analysis of the Biocompatibility and Immune Response of Jellyfish Collagen Scaffolds and its Suitability for Bone Regeneration.International journal of molecular sciences · 2020Article
- Characterization of the Cellular Reaction to a Collagen-Based Matrix: An In Vivo Histological and Histomorphometrical Analysis.Materials (Basel, Switzerland) · 2020Article
- Tissue Integration and Degradation of a Porous Collagen-Based Scaffold Used for Soft Tissue Augmentation.Materials (Basel, Switzerland) · 2020Article
- Platelet-rich fibrin suppresses in vitro osteoclastogenesis.Journal of periodontology · 2020Article
- The Effects of Leukocyte-Platelet Rich Fibrin (L-PRF) on Suppression of the Expressions of the Pro-Inflammatory Cytokines, and Proliferation of Schwann Cell, and Neurotrophic Factors.Scientific reports · 2020Article
- Electrospun PCL/PLA Scaffolds Are More Suitable Carriers of Placental Mesenchymal Stromal Cells Than Collagen/Elastin Scaffolds and Prevent Wound Contraction in a Mouse Model of Wound Healing.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study evaluated the tissue response toward a resorbable collagen membrane derived from bovine achilles tendon (test group) in comparison to physiological wound healing (control group). After subcutaneous implantation in Wistar rats over 30 days, histochemical and immunohistochemical methods elucidated the cellular inflammatory response, vascularization pattern, membrane protein and cell absorbance capacity. After 30 days, the test-group induced two different inflammatory patterns. On the membrane surface, multinucleated giant cells (MNGCs) were formed after the accumulation of CD-68-positive cells (macrophages), whereas only mononuclear cells (MNCs) were found within the membrane central region. Peri-implant vascularization was significantly enhanced after the formation of MNGCs. No vessels were found within the central region of the membrane. Physiological wound healing revealed no MNGCs at any time point. These dynamic changes in the cellular reaction and vascularization within the test-group are related typical indications of a foreign body reaction. Due to the membrane-specific porosity, mononuclear cells migrated into the central region, and the membrane maintained its integrity over 30 days by showing no breakdown or disintegration. The
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.