ArticleFrontiers in chemistry2018
Multi-Detector Characterization of Grape Seed Extract to Enable
Article in Frontiers in chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Safety assessment scheme for menstrual cups and application for the evaluation of a menstrual cup comprised of medical grade silicone.EBioMedicine · 2022Trial
- A multi-detector analytical approach for characterizing complex botanical extracts: a case study on ashwagandha.Analytical and bioanalytical chemistry · 2025Article
- Advancing botanical safety: A strategy for selecting, sourcing, and characterizing botanicals for developing toxicological tools.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2024Article
- Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats.Toxicological research · 2023Article
- Botanical Ingredient Forensics: Detection of Attempts to Deceive Commonly Used Analytical Methods for Authenticating Herbal Dietary and Food Ingredients and Supplements.Journal of natural products · 2023Review
- Chemical Diversity of Flavan-3-Ols in Grape Seeds: Modulating Factors and Quality Requirements.Plants (Basel, Switzerland) · 2022Review
- Optimization of the Extraction of Proanthocyanidins from Grape Seeds Using Ultrasonication-Assisted Aqueous Ethanol and Evaluation of Anti-Steatosis Activity In Vitro.Molecules (Basel, Switzerland) · 2022Article
- Working with the natural complexity: Selection and characterization of black cohosh root extract for use in toxicology testing.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022Article
- Editorial: Advances and Refinements in the Development and Application of Threshold of Toxicological Concern.Frontiers in toxicology · 2022Article
- Origin of Wine Lignans.Plant foods for human nutrition (Dordrecht, Netherlands) · 2021Article
- Review
- Exploitation ofMolecules (Basel, Switzerland) · 2021Article
- Procyanidin-Rich Extract from Grape Seeds as a Putative Tool againstFoods (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Demands for increased analytical rigor have been growing within the botanical and dietary supplement industry due to concerns relative to safety, efficacy, and quality. Adulteration, ambiguous definitions, and insufficient perspective on safety are some of the major issues that arise when selecting a botanical extract. Herein, our comprehensive analytical approach is detailed for the selection of grape seed extracts. This approach provided characterization for the constituents above a threshold of toxicological concern by subjecting the extract to UHPLC-UV-CAD-HRMS and GC-FID & GC-HRMS. Thus, constituents within a wide range of volatility were evaluated. Furthermore, the extract was compared to authenticated botanical materials to confirm that no adulteration took place and was also compared to other grape seed extract sources to confirm that the material falls within the general profile. Finally, these data were cleared via an
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