ArticleChemical science2017
A red-emissive antibody-AIEgen conjugate for turn-on and wash-free imaging of specific cancer cells.
Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 88 citations in OpenAlex.
- Systematic functional screening of switchable aptamer beacon probes.Nature biomedical engineering · 2026Article
- Molecular rotor-based probes for protein monitoring in biomedical research.Nature reviews. Chemistry · 2026Review
- Wash-free fluorescent tools based on organic molecules: Design principles and biomedical applications.Exploration (Beijing, China) · 2025Review
- Detecting Disruption of HER2 Membrane Protein Organization in Cell Membranes with Nanoscale Precision.ACS sensors · 2024Article
- Water-Soluble Aggregation-Induced Emission Luminogens with Near-Infrared Emission for Advanced Phototheranostics.Small science · 2023Article
- Near-Infrared-Emissive AIE Bioconjugates: Recent Advances and Perspectives.Molecules (Basel, Switzerland) · 2022Review
- Real-time imaging of cell-surface proteins with antibody-based fluorogenic probes.Chemical science · 2021Article
- Bright Bacterium for Hypoxia-Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Advances in aggregation induced emission (AIE) materials in biosensing and imaging of bacteria.Progress in molecular biology and translational science · 2021Article
- Recent progress in the molecular imaging of therapeutic monoclonal antibodies.Journal of pharmaceutical analysis · 2020Review
- Supramolecular Hyaluronic Assembly with Aggregation-Induced Emission Mediated in Two Stages for Targeting Cell Imaging.ACS medicinal chemistry letters · 2020Article
- Article
- Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens.Chemical science · 2020Article
- Nanoparticle-based Cell Trackers for Biomedical Applications.Theranostics · 2020Review
- An enzyme-activatable probe liberating AIEgens: on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells.Chemical science · 2019Article
- Near-Infrared Aggregation-Induced Emission-Active Probe EnablesFrontiers in chemistry · 2019Article
- Manipulating and visualizing the dynamic aggregation-induced emission within a confined quartz nanopore.Nature communications · 2018Article
- Exploration of biocompatible AIEgens from natural resources.Chemical science · 2018Article
- Networked Cages for Enhanced COAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An antibody-AIEgen conjugate is designed and developed as a "turn-on" fluorescent probe for wash-free specific cancer cell imaging. The cetuximab-conjugated AIEgen shows red fluorescence only when it is internalized and accumulated in cancer cells with overexpressed epidermal growth factor receptor through endocytosis. The probe first lights up the lysosomes. After hydrolysis, its residue is accumulated in mitochondria, making them highly emissive with a long cell retention time. Compared with conventional "always-on" fluorescent probes, the antibody-AIEgen conjugate exhibits a very good image contrast during wash-free cancer cell imaging and less interference from normal cells. To the best of our knowledge, this is the first time "turn-on" antibody-AIEgen conjugates have been reported. This new strategy can be further extended to many proteins and water-soluble AIEgens, and many of their potential applications such as real-time tracking of cell dynamics and cancer theranostics will be explored. The present work is expected to inspire more marvellous research in the fields of AIE and cancer imaging.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.