Evidence map›Paper›PMID 30155134›Full record

ArticleChemical science2016

Flavoenzyme CrmK-mediated substrate recycling in caerulomycin biosynthesis.

Yiguang Zhu, Marie-Ève Picard, Qingbo Zhang, Julie Barma, Xavier Murphy Després, Xiangui Mei, Liping Zhang, Jean-Baptiste Duvignaud, Manon Couture, Weiming Zhu and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 4 countries.

Yiguang ZhuCAS Key Laboratory of Tropical Marine Bio-resources and Ecology , Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology , Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , China . Email: czhang2006@gmail.com.
Marie-Ève PicardDépartement de biochimie , de microbiologie et de bio-informatique , PROTEO , Institut de Biologie Intégrative et des Systèmes (IBIS) , Université Laval , Québec G1V 0A6 , Canada . Email: rong.shi@bcm.ulaval.ca.
Qingbo ZhangCAS Key Laboratory of Tropical Marine Bio-resources and Ecology , Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology , Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , China . Email: czhang2006@gmail.com.
Julie BarmaDépartement de biochimie , de microbiologie et de bio-informatique , PROTEO , Institut de Biologie Intégrative et des Systèmes (IBIS) , Université Laval , Québec G1V 0A6 , Canada . Email: rong.shi@bcm.ulaval.ca.
Xavier Murphy DesprésDépartement de biochimie , de microbiologie et de bio-informatique , PROTEO , Institut de Biologie Intégrative et des Systèmes (IBIS) , Université Laval , Québec G1V 0A6 , Canada . Email: rong.shi@bcm.ulaval.ca.
Xiangui MeiKey Laboratory of Marine Drugs , Chinese Ministry of Education , School of Medicine and Pharmacy , Ocean University of China , 5 Yushan Road , Qingdao 266003 , China.
Liping ZhangCAS Key Laboratory of Tropical Marine Bio-resources and Ecology , Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology , Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , China . Email: czhang2006@gmail.com.
Jean-Baptiste DuvignaudDépartement de biochimie , de microbiologie et de bio-informatique , PROTEO , Institut de Biologie Intégrative et des Systèmes (IBIS) , Université Laval , Québec G1V 0A6 , Canada . Email: rong.shi@bcm.ulaval.ca.
Manon CoutureDépartement de biochimie , de microbiologie et de bio-informatique , PROTEO , Institut de Biologie Intégrative et des Systèmes (IBIS) , Université Laval , Québec G1V 0A6 , Canada . Email: rong.shi@bcm.ulaval.ca.ORCID 0000-0001-8296-8055
Weiming ZhuKey Laboratory of Marine Drugs , Chinese Ministry of Education , School of Medicine and Pharmacy , Ocean University of China , 5 Yushan Road , Qingdao 266003 , China.
Rong ShiDépartement de biochimie , de microbiologie et de bio-informatique , PROTEO , Institut de Biologie Intégrative et des Systèmes (IBIS) , Université Laval , Québec G1V 0A6 , Canada . Email: rong.shi@bcm.ulaval.ca.
Changsheng ZhangCAS Key Laboratory of Tropical Marine Bio-resources and Ecology , Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology , Chinese Academy of Sciences , 164 West Xingang Road , Guangzhou 510301 , China . Email: czhang2006@gmail.com.
Département de Chimie Moléculaire · FRChinese Academy of Sciences · CNMinistry of Education · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Substrate salvage or recycling is common and important for primary metabolism in cells but is rare in secondary metabolism. Herein we report flavoenzyme CrmK-mediated shunt product recycling in the biosynthesis of caerulomycin A (CRM A

Identifiers

PMID30155134
PMCPMC6016722
OpenAlexW2341397174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.