ArticleChemical science2016
Self-assembly of nucleic acid molecular aggregates catalyzed by a triple-helix probe for miRNA detection and single cell imaging.
Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The nucleic acid reactions on the nanomaterials surface for biomedicine.Journal of nanobiotechnology · 2025Review
- Single-Cell Imaging of mRNA by Target RNA-Initiated RCA.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Electrochemical biosensor strategy combining DNA entropy-driven technology to activate CRISPR-Cas13a activity and triple-stranded nucleic acids to detect SARS-CoV-2 RdRp gene.Mikrochimica acta · 2023Article
- Optical Biosensors for the Detection of Rheumatoid Arthritis (RA) Biomarkers: A Comprehensive Review.Sensors (Basel, Switzerland) · 2020Review
- Near-infrared triggered strand displacement amplification for MicroRNA quantitative detection in single living cells.Chemical science · 2018Article
- Imaging multiple microRNAs in living cells using ATP self-powered strand-displacement cascade amplification.Chemical science · 2018Article
- Catalytic hairpin assembly gel assay for multiple and sensitive microRNA detection.Theranostics · 2018Article
- Simultaneous visualization of the subfemtomolar expression of microRNA and microRNA target gene using HILO microscopy.Chemical science · 2017Article
- Highly specific imaging of mRNA in single cells by target RNA-initiated rolling circle amplification.Chemical science · 2017Article
- A smart ZnO@polydopamine-nucleic acid nanosystem for ultrasensitive live cell mRNA imaging by the target-triggered intracellular self-assembly of active DNAzyme nanostructures.Chemical science · 2017Article
- Label-free detection of microRNA based on coupling multiple isothermal amplification techniques.Scientific reports · 2016Article
- Core-shell self-assembly triggered via a thiol-disulfide exchange reaction for reduced glutathione detection and single cells monitoring.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We herein report a novel finding that nucleic acid molecular aggregates (NAMAs) self-assembled on graphene oxide nanoplates (GONPs) as a result of DNA rolling circle amplification (RCA) and a functionalized triple-helix probe (THP) in single cells. The functionalized THP containing the aptamer region for target recognition and the trigger DNA region for RCA was firstly used to activate RCA for miRNA imaging in single cells. Interestingly, NAMAs with the fluorescent labels were hybridized by both the RCA products and FAM-DNA, and could partly self-assemble on GONPs; meanwhile, NAMAs could extend from the GONPs, which led to the quenched fluorescence being renewed. Significantly, the NAMAs were successfully applied for low-abundance miRNA detection and imaging in single cells. The self-assembled NAMAs could generate prominent and agminated fluorescence-bright spots in single cancer cells, which will effectively drive cell imaging into a new era.
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Registered trials
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