Evidence map›Paper›PMID 30155060›Full record

ArticleChemical science2016

On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan.

Tristin E Rose, Brice H Curtin, Kenneth V Lawson, Adam Simon, K N Houk, Patrick G Harran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Computational generation of an annotated gigalibrary of synthesizable, composite peptidic macrocycles.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tristin E RoseDepartment of Chemistry and Biochemistry , University of California Los Angeles , 607 Charles E. Young Drive East , Los Angeles , California 90095 , USA . Email: harran@chem.ucla.edu.
Brice H CurtinDepartment of Chemistry and Biochemistry , University of California Los Angeles , 607 Charles E. Young Drive East , Los Angeles , California 90095 , USA . Email: harran@chem.ucla.edu.
Kenneth V LawsonDepartment of Chemistry and Biochemistry , University of California Los Angeles , 607 Charles E. Young Drive East , Los Angeles , California 90095 , USA . Email: harran@chem.ucla.edu.
Adam SimonDepartment of Chemistry and Biochemistry , University of California Los Angeles , 607 Charles E. Young Drive East , Los Angeles , California 90095 , USA . Email: harran@chem.ucla.edu.
K N HoukDepartment of Chemistry and Biochemistry , University of California Los Angeles , 607 Charles E. Young Drive East , Los Angeles , California 90095 , USA . Email: harran@chem.ucla.edu.
Patrick G HarranDepartment of Chemistry and Biochemistry , University of California Los Angeles , 607 Charles E. Young Drive East , Los Angeles , California 90095 , USA . Email: harran@chem.ucla.edu.

Funding

CHEMISTRY BIOLOGY INTERFACE TRAINING PROGRAMT32GM008496 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYNARD, HEATHER D · 1993 to 2019
$6.3M
Fully Synthetic Prodiginines as Probes of Protein-Protein Interactions RegulatingR01CA184772 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARRAN, PATRICK G. · 2014 to 2019
$1.8M
NCI NIH HHS R01 CA184772NIGMS NIH HHS T32 GM008496
6 · The paper itself

Abstract

A Friedel-Crafts alkylation is described that efficiently transforms tryptophan-containing peptides into macrocycles of varying ring connectivity. Factors are surveyed that influence the distribution of regioisomers, with a focus on indole C3-alkylations leading to bridged

Identifiers

PMID30155060
PMCPMC6014094

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.