ArticleChemical science2016
Mechanistically informed predictions of binding modes for carbocation intermediates of a sesquiterpene synthase reaction.
Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Terpene synthases screening in agarwood treeSynthetic and systems biotechnology · 2027Article
- Reinvestigation of the mechanism and selectivity of 1,8-cineole synthase usingChemical science · 2026Article
- A methionine-lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase.FEBS letters · 2026Article
- Peeking behind the carbocation: identification of (alternative) catalytic bases in the class II active site of conifer resin acid diterpene synthases.The Biochemical journal · 2026Article
- Characterization and functional reconstruction of a highly productive germacrene A synthase from Liriodendron chinense.Plant biotechnology journal · 2025Article
- Single Point Mutation Abolishes Water Capture in Germacradien-4-ol Synthase.Chembiochem : a European journal of chemical biology · 2024Article
- Simulation-Guided Engineering Enables a Functional Switch in Selinadiene Synthase toward Hydroxylation.ACS catalysis · 2024Article
- Mechanistic docking in terpene synthases using EnzyDock.Methods in enzymology · 2024Review
- Investigation of Acid-Base Catalysis in Halimadienyl Diphosphate Synthase Involved inACS bio & med chem Au · 2022Article
- Predictive Engineering of Class I Terpene Synthases Using Experimental and Computational Approaches.Chembiochem : a European journal of chemical biology · 2022Review
- Mining methods and typical structural mechanisms of terpene cyclases.Bioresources and bioprocessing · 2021Review
- Stereoselective Directed Cationic Cascades Enabled by Molecular Anchoring in Terpene Cyclases.Angewandte Chemie (International ed. in English) · 2021Article
- Crystal Structure and Mechanistic Molecular Modeling Studies ofBiochemistry · 2020Article
- Development of potent inhibitors of the human microsomal epoxide hydrolase.European journal of medicinal chemistry · 2020Article
- Comparative (Within Species) Genomics of theFrontiers in genetics · 2020Article
- Switching on a Nontraditional Enzymatic Base - Deprotonation by Serine in theACS catalysis · 2019Article
- Experiment and Simulation Reveal How Mutations in Functional Plasticity Regions Guide Plant Monoterpene Synthase Product Outcome.ACS catalysis · 2019Article
- Linking Terpene Synthases to Sesquiterpene Metabolism in Grapevine Flowers.Frontiers in plant science · 2019Article
- Inherent atomic mobility changes in carbocation intermediates during the sesterterpene cyclization cascade.Beilstein journal of organic chemistry · 2019Article
- Acceleration of Mechanistic Investigation of Plant Secondary Metabolism Based on Computational Chemistry.Frontiers in plant science · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sesquiterpenoids comprise a class of terpenoid natural products with thousands of compounds that are highly diverse in structure, generally containing a polycyclic carbon backbone that is constructed by a sesquiterpene synthase. Decades of experimental and computational studies have demonstrated that these enzymes generate a carbocation in the active site, which undergoes a series of structural rearrangements until a product is formed
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.