ArticleChemical science2016
Wide-field tissue polarimetry allows efficient localized mass spectrometry imaging of biological tissues.
Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Reflection mode polarimetry guides laser mass spectrometry to diagnostically important regions of human breast cancer tissue.Scientific reports · 2024Article
- Emerging Computational Methods in Mass Spectrometry Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- High-Throughput Mass Spectrometry Imaging with Dynamic Sparse Sampling.ACS measurement science au · 2022Article
- Optical Metasurfaces for Energy Conversion.Chemical reviews · 2022Review
- Self-supervised clustering of mass spectrometry imaging data using contrastive learning.Chemical science · 2021Article
- Multiplatform Investigation of Plasma and Tissue Lipid Signatures of Breast Cancer Using Mass Spectrometry Tools.International journal of molecular sciences · 2020Article
- A multiscale Mueller polarimetry module for a stereo zoom microscope.Biomedical engineering letters · 2019Article
- Ambient Ionization Mass Spectrometry: Recent Developments and Applications.Analytical chemistry · 2019Review
- PhaseStain: the digital staining of label-free quantitative phase microscopy images using deep learning.Light, science & applications · 2019Article
- Second-harmonic patterned polarization-analyzed reflection confocal microscopy of stromal collagen in benign and malignant breast tissues.Scientific reports · 2018Article
- A Sensitive and Wide Coverage Ambient Mass Spectrometry Imaging Method for Functional Metabolites Based Molecular Histology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies.Scientific reports · 2018Article
- Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights.Analytical chemistry · 2018Review
- Real time complete Stokes polarimetric imager based on a linear polarizer array camera for tissue polarimetric imaging.Biomedical optics express · 2017Article
- Flexible polarimetric probe for 3 × 3 Mueller matrix measurements of biological tissue.Scientific reports · 2017Article
- Optimized Mass Spectrometry Analysis Workflow with Polarimetric Guidance for ex vivo and in situ Sampling of Biological Tissues.Scientific reports · 2017Article
- An Assessment of the Utility of Tissue Smears in Rapid Cancer Profiling with Desorption Electrospray Ionization Mass Spectrometry (DESI-MS).Journal of the American Society for Mass Spectrometry · 2017Article
- Article
- Rapid Detection of Necrosis in Breast Cancer with Desorption Electrospray Ionization Mass Spectrometry.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While mass spectrometers can detect chemical signatures within milliseconds of data acquisition time, the non-targeted nature of mass spectrometry imaging (MSI) necessitates probing the entire surface of the sample to reveal molecular composition even if the information is only sought from a sample subsection. This leads to long analysis times. Here, we used polarimetry to identify, within a biological tissue, areas of polarimetric heterogeneity indicative of cancer. We were then able to target our MS analysis using polarimetry results to either the cancer region itself or to the cancer margin. A tandem of polarimetry and Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) enables fast (10 fold compared to non-targeted imaging), and accurate pathology assessment (cancer typification in less than 2 minutes compared to 30 minutes for histopathology) of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.