ArticleChemical science2015
Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues.
Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Rapid building block-economic synthesis of long, multi-Chemical science · 2024Article
- Improved Handling of Peptide Segments Using Side Chain-Based "Helping Hand" Solubilizing Tools.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Traceless parallel peptide purification by a first-in-class reductively cleavable linker system featuring a safety-release.Chemical science · 2021Article
- A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation.Chemical science · 2021Article
- On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins.Journal of the American Chemical Society · 2020Article
- Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology.Journal of medicinal chemistry · 2020Review
- Synthesis of hydrophobic insulin-based peptides using a helping hand strategy.Organic & biomolecular chemistry · 2019Article
- Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation.Chemical science · 2018Article
- A simple and traceless solid phase method simplifies the assembly of large peptides and the access to challenging proteins.Chemical science · 2017Article
- Total chemical synthesis of proteins without HPLC purification.Chemical science · 2016Article
- A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis.Journal of the American Chemical Society · 2016Article
- Hybrid phase ligation for efficient synthesis of histone proteins.Organic & biomolecular chemistry · 2016Article
- All about that Amide Bond: The Sixth Chemical Protein Synthesis (CPS) Meeting.Chembiochem : a European journal of chemical biology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The solid-phase chemical assembly of a protein through iterative chemoselective ligation of unprotected peptide segments can be followed with chemical and/or enzymatic transformations of the resulting immobilized protein, the latter steps thus benefitting from the advantages provided by the solid support. We demonstrate here the usefulness of this strategy for the chemo-enzymatic synthesis of glycoprotein analogues. A linker was specifically designed for application to the synthesis of
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.