Evidence map›Paper›PMID 30154939›Full record

ArticleDisease markers2018

Genetic Polymorphisms Associated with Environmental Exposure to Polycyclic Derivatives in African Children.

Rodrigo Mota de Oliveira, Camylla Vilas Boas Figueiredo, Rayra Pereira Santiago, Sètondji Cocou Modeste Alexandre Yahouédéhou, Suéllen Pinheiro Carvalho, Silvana Souza da Paz, Luciana Magalhães Fiuza, Fernando Nunes de Miranda, Caroline Conceição da Guarda, Cleverson Alves Fonseca and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Rodrigo Mota de OliveiraLaboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo, no. 147, Ondina, 40.170-115 Salvador, BA, Brazil.
Camylla Vilas Boas FigueiredoLaboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo, no. 147, Ondina, 40.170-115 Salvador, BA, Brazil.
Rayra Pereira SantiagoLaboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo, no. 147, Ondina, 40.170-115 Salvador, BA, Brazil.
Sètondji Cocou Modeste Alexandre YahouédéhouLaboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo, no. 147, Ondina, 40.170-115 Salvador, BA, Brazil.
Suéllen Pinheiro CarvalhoLaboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo, no. 147, Ondina, 40.170-115 Salvador, BA, Brazil.
Silvana Souza da PazLaboratório de Investigação em Genética e Hematologia Translacional (LIGHT), Instituto Gonçalo Moniz (IGM), FIOCRUZ, Rua Waldemar Falcão, 121 Candeal, 40.296-710 Salvador, BA, Brazil.
Luciana Magalhães FiuzaLaboratório de Investigação em Genética e Hematologia Translacional (LIGHT), Instituto Gonçalo Moniz (IGM), FIOCRUZ, Rua Waldemar Falcão, 121 Candeal, 40.296-710 Salvador, BA, Brazil.
Fernando Nunes de MirandaLaboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo, no. 147, Ondina, 40.170-115 Salvador, BA, Brazil.
Caroline Conceição da GuardaLaboratório de Investigação em Genética e Hematologia Translacional (LIGHT), Instituto Gonçalo Moniz (IGM), FIOCRUZ, Rua Waldemar Falcão, 121 Candeal, 40.296-710 Salvador, BA, Brazil.
Cleverson Alves FonsecaLaboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo, no. 147, Ondina, 40.170-115 Salvador, BA, Brazil.
Milena Magalhães AleluiaLaboratório de Investigação em Genética e Hematologia Translacional (LIGHT), Instituto Gonçalo Moniz (IGM), FIOCRUZ, Rua Waldemar Falcão, 121 Candeal, 40.296-710 Salvador, BA, Brazil.
Cynara Gomes BarbosaLaboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo, no. 147, Ondina, 40.170-115 Salvador, BA, Brazil.
Elisângela Vitória AdornoLaboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo, no. 147, Ondina, 40.170-115 Salvador, BA, Brazil.
Marilda de Souza GonçalvesLaboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo, no. 147, Ondina, 40.170-115 Salvador, BA, Brazil.ORCID 0000-0003-3000-1437
Universidade Federal da Bahia · BRFundação Oswaldo Cruz · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe nonracial leukopenia may be a result of exposure to polycyclic derivatives (benzene-toluene-xylene (BTX)) and may arise from a possible change in the bone marrow microenvironment. The present study sought to evaluate the association of genetic polymorphisms in xenobiotic-metabolizing enzymes with hematological and biochemical profiles.

methodsWe evaluated 89 African descendant children, exposed indirectly to benzene derivatives. Laboratory parameters were investigated by automated methods and genetic polymorphisms by PCR-RFLP and PCR multiplex.

resultsChildren with leukopenia had significantly decreased white blood cells (WBCs) and platelet counts, which is not consistent with benign leukopenia. In the same group, we have found that carriers of the

conclusionOur results suggest that the polymorphisms investigated were associated with hematological changes in the studied population. These alterations could be heightened by exposure to benzene derivatives.

Indexed as

Polymorphism, GeneticAmplified Fragment Length Polymorphism AnalysisBenzene DerivativesBlack PeopleBrazilChildCross-Sectional StudiesCytochrome P-450 CYP2E1Environmental ExposureFemaleGlutathione TransferaseHumansLeukopeniaMaleMultiplex Polymerase Chain ReactionNAD(P)H Dehydrogenase (Quinone)Benzene DerivativesCytochrome P-450 CYP2E1Glutathione TransferaseMPO protein, humanNAD(P)H Dehydrogenase (Quinone)NQO1 protein, humanPeroxidase

Identifiers

PMID30154939
PMCPMC6092976
OpenAlexW2887045993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.