Evidence map›Paper›PMID 30154825›Full record

ArticleFrontiers in genetics2018

To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes.

Amelia D Wallace, George A Wendt, Lisa F Barcellos, Adam J de Smith, Kyle M Walsh, Catherine Metayer, Joseph F Costello, Joseph L Wiemels, Stephen S Francis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
8.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  4. Human Endogenous Retrovirus K in Astrocytes Is Altered in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
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  6. Article
  7. Microorganisms · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Amelia D WallaceDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States.
George A WendtDivision of Epidemiology, School of Community Health Sciences, University of Nevada, Reno, NV, United States.
Lisa F BarcellosDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States.
Adam J de SmithDepartment of Epidemiology and Biostatistics, Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States.
Kyle M WalshDepartment of Neurosurgery, Duke University, Durham, NC, United States.
Catherine MetayerDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA, United States.
Joseph F CostelloDepartment of Neurosurgery, Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States.
Joseph L WiemelsDepartment of Epidemiology and Biostatistics, Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States.
Stephen S FrancisDivision of Epidemiology, School of Community Health Sciences, University of Nevada, Reno, NV, United States.
UCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of California, Berkeley · USDuke University · USUniversity of California, San Francisco · USUniversity of Nevada, Reno · US

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4M
Project 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang, Janine Marie Lupo · 2007 to 2026
$44.7M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Imaging Guided Genomics of Malignant TransformationR01CA169316 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COSTELLO, JOSEPH F · 2013 to 2017
$3.0M
HKLE-seq: an enrichment method for unbiased amplification and next-generation sequencing of all HERV-K and SVA (HKLE) insertion breakpoints genome-wide in human DNA samplesR15GM126562 · NIGMS · UNIVERSITY OF NEVADA RENO · PI RYU, SO YOUNG · 2018 to 2018
$430k
NCI NIH HHS P01 CA118816NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA169316NCI NIH HHS T32 CA151022NIGMS NIH HHS R15 GM126562
6 · The paper itself

Abstract

Approximately 8% of the human genome is comprised of endogenous retroviral insertions (ERVs) originating from historic retroviral integration into germ cells. The function of ERVs as regulators of gene expression is well established. Less well studied are insertional polymorphisms of ERVs and their contribution to the heritability of complex phenotypes. The most recent integration of ERV, HERV-K, is expressed in a range of complex human conditions from cancer to neurologic diseases. Using an in-house computational pipeline and whole-genome sequencing data from the diverse 1,000 Genomes Phase 3 population (

Indexed as

eQTLGWASHERV-Kpolymorphismrecombination

Identifiers

PMID30154825
PMCPMC6102640
OpenAlexW2886200369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.