Evidence map›Paper›PMID 30154788›Full record

ArticleFrontiers in immunology2018

Joint Modeling of Immune Reconstitution Post Haploidentical Stem Cell Transplantation in Pediatric Patients With Acute Leukemia Comparing CD34

Emilia Salzmann-Manrique, Melanie Bremm, Sabine Huenecke, Milena Stech, Andreas Orth, Matthias Eyrich, Ansgar Schulz, Ruth Esser, Thomas Klingebiel, Peter Bader and 2 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Acute graft-versus-host disease.Nature reviews. Disease primers · 2023
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. T-Cell-Replete VersusFrontiers in pediatrics · 2021
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Emilia Salzmann-ManriqueDepartment of Medicine, Institute of Biostatistics and Mathematical Modeling, Johann Wolfgang Goethe-University, Frankfurt, Germany.
Melanie BremmPediatric Hematology and Oncology, Johann Wolfgang Goethe-University, Frankfurt, Germany.
Sabine HueneckePediatric Hematology and Oncology, Johann Wolfgang Goethe-University, Frankfurt, Germany.
Milena StechPediatric Hematology and Oncology, Johann Wolfgang Goethe-University, Frankfurt, Germany.
Andreas OrthUniversity of Applied Sciences Frankfurt, Frankfurt, Germany.
Matthias EyrichPediatric Hematology and Oncology, University of Wuerzburg, Wuerzburg, Germany.
Ansgar SchulzPediatric Hematology and Oncology, University of Ulm, Ulm, Germany.
Ruth EsserInstitute of Cellular Therapeutics Hannover Medical School, Hannover, Germany.
Thomas KlingebielPediatric Hematology and Oncology, Johann Wolfgang Goethe-University, Frankfurt, Germany.
Peter BaderPediatric Hematology and Oncology, Johann Wolfgang Goethe-University, Frankfurt, Germany.
Eva HerrmannDepartment of Medicine, Institute of Biostatistics and Mathematical Modeling, Johann Wolfgang Goethe-University, Frankfurt, Germany.
Ulrike KoehlInstitute of Cellular Therapeutics Hannover Medical School, Hannover, Germany.
Goethe University Frankfurt · DEFrankfurt University of Applied Sciences · DEFraunhofer Institute for Cell Therapy and Immunology · DEMedizinische Hochschule Hannover · DEUniversität Ulm · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid immune reconstitution (IR) following stem cell transplantation (SCT) is essential for a favorable outcome. The optimization of graft composition should not only enable a sufficient IR but also improve graft vs. leukemia/tumor effects, overcome infectious complications and, finally, improve patient survival. Especially in haploidentical SCT, the optimization of graft composition is controversial. Therefore, we analyzed the influence of graft manipulation on IR in 40 patients with acute leukemia in remission. We examined the cell recovery post haploidentical SCT in patients receiving a CD34

Indexed as

Hematopoietic Stem Cell TransplantationImmune ReconstitutionLymphocyte DepletionAdolescentAdultAntigens, CD19BiomarkersCD3 ComplexChildChild, PreschoolFemaleHumansImmunophenotypingInfantLeukemia, Myeloid, AcuteLymphocytesAntigens, CD19BiomarkersCD3 Complexallogeneic stem cell transplantationCD3/19 depletionCD34 selectionchildrenimmune reconstitution

Identifiers

PMID30154788
PMCPMC6102342
OpenAlexW2887562722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.