Evidence map›Paper›PMID 30154721›Full record

ArticleFrontiers in pharmacology2018

Controlled Drug Delivery by Polylactide Stereocomplex Micelle for Cervical Cancer Chemotherapy.

Kai Niu, Yunming Yao, Ming Xiu, Chunjie Guo, Yuanyuan Ge, Jianmeng Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Therapeutic applications of nanobiotechnology.Journal of nanobiotechnology · 2023
    Review
  5. Review
  6. Review
  7. Applications of PLA in modern medicine.Engineered regeneration · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kai NiuDepartment of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Jilin University, Changchun, China.
Yunming YaoDepartment of Abdominal Ultrasound, The First Hospital of Jilin University, Changchun, China.
Ming XiuDepartment of Intensive Care Unit, The First Hospital of Jilin University, Changchun, China.
Chunjie GuoDepartment of Radiology, The First Hospital of Jilin University, Changchun, China.
Yuanyuan GeDepartment of Geriatrics, The First Hospital of Jilin University, Changchun, China.
Jianmeng WangDepartment of Geriatrics, The First Hospital of Jilin University, Changchun, China.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A stable doxorubicin (DOX)-loaded stereocomplex micelle drug delivery system was developed via the stereocomplex interaction between enantiomeric 4-armed poly(ethylene glycol)-poly(D-lactide) and poly(ethylene glycol)-poly(L-lactide) to realize control drug release and improve tumor cell uptake for efficient cervical carcinoma therapy. All these DOX-loaded micelles including poly(D-lactide)-based micelle (PDM/DOX), poly(L-lactide)-based micelle (PLM/DOX), and stereocomplex micelle (SCM/DOX) exhibited appropriate sizes of ∼100 nm for the enhanced permeability and retention (EPR) effect. In addition, compared to PDM/DOX and PLM/DOX, SCM/DOX exhibited the slowest DOX releaser, highest tumor cell uptake and the most efficient tumor cell suppression

Indexed as

cervical carcinomachemotherapycontrolled drug deliveryenhanced stabilitystereocomplex polylactide micelle

Identifiers

PMID30154721
PMCPMC6102361
OpenAlexW2886753449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.