ArticleFrontiers in cellular neuroscience2018
Sodium-Calcium Exchanger Can Account for Regenerative Ca
Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Microglia-astrocyte crosstalk following ischemic stroke.Molecular brain · 2025Review
- Article
- Revisiting astrocytic calcium signaling in the brain.Fundamental research · 2024Review
- Astrocytes: new evidence, new models, new roles.Biophysical reviews · 2023Review
- Modeling the heterogeneity of sodium and calcium homeostasis between cortical and hippocampal astrocytes and its impact on bioenergetics.Frontiers in cellular neuroscience · 2023Article
- Astrocytic modulation of neuronal signalling.Frontiers in network physiology · 2023Review
- Calcium signaling in astrocytes and gliotransmitter release.Frontiers in synaptic neuroscience · 2023Review
- Characterizing spontaneous CaBiophysical journal · 2022Article
- The Development of Novel Drug Treatments for Stroke Patients: A Review.International journal of molecular sciences · 2022Review
- Activation of Glutamate Transport Increases Arteriole DiameterFrontiers in cellular neuroscience · 2022Article
- Astrocyte Gliotransmission in the Regulation of Systemic Metabolism.Metabolites · 2021Review
- Extracellular Calcium Influx Pathways in Astrocyte Calcium Microdomain Physiology.Biomolecules · 2021Review
- The NaFrontiers in pharmacology · 2021Article
- Spontaneous CaFrontiers in cellular neuroscience · 2021Article
- Making sense of astrocytic calcium signals - from acquisition to interpretation.Nature reviews. Neuroscience · 2020Review
- Review
- Astrocytic Calcium Dynamics Along the Pain Pathway.Frontiers in cellular neuroscience · 2020Review
- Heterogeneity of Activity-Induced Sodium Transients between Astrocytes of the Mouse Hippocampus and Neocortex: Mechanisms and Consequences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium transients in thin astrocytic processes can be important in synaptic plasticity, but their mechanism is not completely understood. Clearance of synaptic glutamate leads to increase in astrocytic sodium. This can electrochemically favor the reverse mode of the Na/Ca-exchanger (NCX) and allow calcium into the cell, accounting for activity-dependent calcium transients in perisynaptic astrocytic processes. However, cytosolic sodium and calcium are also allosteric regulators of the NCX, thus adding kinetic constraints on the NCX-mediated fluxes and providing for complexity of the system dynamics. Our modeling indicates that the calcium-dependent activation and also calcium-dependent escape from the sodium-mediated inactive state of the NCX in astrocytes can form a positive feedback loop and lead to regenerative calcium influx. This can result in sodium-dependent amplification of calcium transients from nearby locations or other membrane mechanisms. Prolonged conditions of elevated sodium, for example in ischemia, can also lead to bistability in cytosolic calcium levels, where a delayed transition to the high-calcium state can be triggered by a short calcium transient. These theoretical predictions call for a dedicated experimental estimation of the kinetic parameters of the astrocytic Na/Ca-exchanger.
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