ArticleNeuropsychiatric disease and treatment2018
Investigation of chromosome Y loss in men with schizophrenia.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Loss of chromosome Y in hematopoietic cells: mechanisms and implications for human disease.MedScience · 2026Review
- The effects of loss of Y chromosome on male health.Nature reviews. Genetics · 2025Review
- The impact of mosaic loss of the Y chromosome (mLOY) in men of advanced age.Biogerontology · 2024Review
- Determination of loss of chromosome Y in peripheral blood cells in males with idiopathic pulmonary fibrosis.The European respiratory journal · 2024Article
- Mosaic Chromosomal Alterations Are Associated With Increased Lung Cancer Risk: Insight From the INTEGRAL-ILCCO Cohort Analysis.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2023Article
- Characterization of loss of chromosome Y in peripheral blood cells in male Han Chinese patients with schizophrenia.BMC psychiatry · 2023Article
- Chromosomal and gonadal factors regulate microglial sex effects in the aging brain.Brain research bulletin · 2023Review
- Sex-limited chromosomes and non-reproductive traits.BMC biology · 2022Review
- Germline risk of clonal haematopoiesis.Nature reviews. Genetics · 2021Review
- Deletions on Chromosome Y and Downregulation of theCancers · 2021Article
- Chromosome Y loss and drivers of clonal hematopoiesis in myelodysplastic syndrome.Haematologica · 2021Article
- Mosaic loss of human Y chromosome: what, how and why.Human genetics · 2020Review
- Insights into the loss of the Y chromosome with age in control individuals and in patients with age-related macular degeneration using genotyping microarray data.Human genetics · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLife expectancy is 10-20 years lower in patients with schizophrenia than in the general population. In addition, men with schizophrenia have an earlier age at onset, more pronounced deficit symptoms, poorer course, and poorer response to antipsychotic medications than women. Recent studies have indicated that loss of chromosome Y (LOY) in peripheral blood is associated with an increased risk of all-cause mortality. In order to elucidate the pathophysiology of male-specific features, we investigated the association between LOY and schizophrenia. MATERIALS AND
methodsThe present study included 360 Japanese men (146 patients with schizophrenia vs 214 controls). The relative amount of Y chromosome was defined as the ratio of chromosome Y to chromosome X (Y/X ratio) based on the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (
resultsThere was no significant difference in the frequency of LOY between the schizophrenia and control groups. However, longer duration of illness was associated with LOY after controlling for age and smoking status in the schizophrenia group (
conclusionAccording to our results, schizophrenia may not have a remarkable effect on blood LOY; however, LOY may be associated with disease course in patients with schizophrenia.
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