ArticleNature communications2018
Intermolecular selective carboacylation of alkenes via nickel-catalyzed reductive radical relay.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
43 citing papers in PubMed.
- Nickel-Catalyzed Twofold Conjunctive Coupling via Philicity-Alternating Radical Relay.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Defluorinative Cyclization of Enamides with Fluoroalkyl Halides Through Two Vicinal C(spAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- β,β-Difluoro Peroxides as Fluorinated C2-Building Blocks for the Construction of Functionalized Indolizines.Molecules (Basel, Switzerland) · 2024Article
- Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis.Chemical reviews · 2024Review
- The Divergent Reactivity of Acid Chlorides Under Transition Metal Catalysis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Review
- Kinetics and Mechanism of PPhJournal of the American Chemical Society · 2024Article
- Regiodivergent Radical-Relay Alkene Dicarbofunctionalization.Journal of the American Chemical Society · 2024Article
- Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes.Molecules (Basel, Switzerland) · 2024Article
- Chemo-, regio- and stereoselective access to polysubstituted 1,3-dienes via Nickel-catalyzed four-component reactions.Nature communications · 2024Article
- Nickel/photoredox-catalyzed three-component silylacylation of acrylatesChemical science · 2024Article
- Ligand Relay for Nickel-Catalyzed Decarbonylative Alkylation of Aroyl Chlorides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Ketones from aldehydes via alkyl C(spNature communications · 2023Article
- Dual Nickel/Photoredox-Catalyzed Asymmetric Carbosulfonylation of Alkenes.Journal of the American Chemical Society · 2023Article
- Article
- Regioselective Ni-Catalyzed reductive alkylsilylation of acrylonitrile with unactivated alkyl bromides and chlorosilanes.Nature communications · 2022Article
- Photoredox cooperative N-heterocyclic carbene/palladium-catalysed alkylacylation of alkenes.Nature communications · 2022Article
- Synthesis of Vicinal Carbocycles by Intramolecular Nickel-Catalyzed Conjunctive Cross-Electrophile Coupling Reaction.Organic letters · 2022Article
- Nickel-Catalyzed Tandem Ueno-Stork Cyclization: Stereoselective 1,2-Dicarbofunctionalization of Cyclic Alkenes.The Journal of organic chemistry · 2022Article
- Three-component carboacylation of alkenesChemical science · 2022Article
- Ni-Catalyzed Regio- and Stereoselective Alkylarylation of Unactivated Alkenes in γ,δ-Alkenylketimines.ACS catalysis · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The development of catalytic carboacylation of simple olefins, which would enable the rapid construction of ketones with high levels of complexity and diversity, is very challenging. To date, the vast majority of alkene carboacylation reactions are typically restricted to single- and two-component methodologies. Here we describe a three-component carboacylation of alkenes via the merger of radical chemistry with nickel catalysis. This reaction manifold utilizes a radical relay strategy involving radical addition to an alkene followed by alkyl radical capture by an acyl-nickel complex to forge two vicinal C-C bonds under mild conditions. Excellent chemoselectivity and regioselectivity have been achieved by utilizing a pendant weakly chelating group. This versatile protocol allows for facile access to a wide range of important β-fluoroalkyl ketones from simple starting materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.